Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.46 |
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | USP2 | O75604 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7990353 | 0.83 | KDM4E (0.52) | RAB9AMAPK1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL5386406 | 0.82 | HSD17B10 (0.45) | MAPK1ALDH1A1HSD17B10CYP2C19CYP1A2 | |
| SCHEMBL7447432 | 0.81 | HSD17B10 (0.47) | RAB9AMAPK1TSHRALDH1A1HPGD | |
| SCHEMBL7996176 | 0.80 | SMO (0.51) | MAPTGAAALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL7978276 | 0.80 | HRH4 (0.49) | — | |
| SCHEMBL7989788 | 0.79 | ALDH1A1 (0.58) | MAPTGAAMAPK1TSHRALDH1A1 | |
| SCHEMBL5381026 | 0.79 | AR (0.44) | MAPTGAATSHRALDH1A1HSD17B10 | |
| SCHEMBL7978522 | 0.78 | — | — | |
| SCHEMBL7978711 | 0.76 | POLB (0.46) | TSHRALDH1A1HSD17B10LMNAUSP2 | |
| SCHEMBL7989638 | 0.76 | F10 (0.38) | MAPTMAPK1HSD17B10CDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001070728-A1 | 2-[NITROGEN-HETEROCYCLIC]PYRIMIDONE DERIVATIVES | SANOFI-SYNTHELABO (FR) | 2001-09-27 | — | — | WO | disclosed |