Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 9/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.35 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | MARK3 | P27448 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.35 |
| ▸ | CLK2 | P49760 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | CDK7 | P50613 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7447432 | 0.78 | HSD17B10 (0.47) | CDC7GSK3BROCK2ROCK1DYRK3 | |
| SCHEMBL5386406 | 0.77 | HSD17B10 (0.45) | CDC7GSK3BROCK2ROCK1DYRK3 | |
| SCHEMBL5381026 | 0.71 | AR (0.44) | CDC7GSK3BCDK2DBF4 | |
| SCHEMBL5386023 | 0.68 | CDC7 (0.44) | CDC7GSK3BROCK2ROCK1DYRK3 | |
| SCHEMBL7989788 | 0.68 | ALDH1A1 (0.58) | MAPK1 | |
| SCHEMBL7978699 | 0.67 | MAPT (0.52) | CDC7MAPK1 | |
| SCHEMBL7993007 | 0.67 | KDM4E (0.45) | — | |
| SCHEMBL5390628 | 0.66 | CDC7 (0.52) | CDC7GSK3BROCK2ROCK1DYRK3 | |
| SCHEMBL7978276 | 0.66 | HRH4 (0.49) | KIT | |
| SCHEMBL7990353 | 0.65 | KDM4E (0.52) | MAPK1HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001070728-A1 | 2-[NITROGEN-HETEROCYCLIC]PYRIMIDONE DERIVATIVES | SANOFI-SYNTHELABO (FR) | 2001-09-27 | — | — | WO | disclosed |