Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 7/20 | 0.53 |
| ▸ | NOS1 | P29475 | 7/20 | 0.53 |
| ▸ | NOS2 | P35228 | 7/20 | 0.53 |
| ▸ | MCHR1 | Q99705 | 8/20 | 0.43 |
| ▸ | IDH1 | O75874 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5833846 | 0.76 | NOS3 (0.69) | NOS3NOS1NOS2MCHR1 | |
| SCHEMBL10169414 | 0.70 | HRH3 (0.49) | — | |
| SCHEMBL5833564 | 0.70 | NOS3 (1.00) | NOS3NOS1NOS2MCHR1 | |
| SCHEMBL6699975 | 0.69 | NOS3 (0.46) | NOS3NOS1NOS2 | |
| SCHEMBL7447975 | 0.69 | ALOX5AP (0.48) | NOS3NOS1NOS2MCHR1 | |
| SCHEMBL5833018 | 0.69 | NOS3 (0.72) | NOS3NOS1NOS2MCHR1 | |
| SCHEMBL5833380 | 0.68 | NOS3 (0.89) | NOS3NOS1NOS2MCHR1 | |
| SCHEMBL6702828 | 0.68 | NOS3 (0.45) | NOS3NOS1NOS2 | |
| SCHEMBL6697919 | 0.68 | NOS3 (0.45) | NOS3NOS1NOS2 | |
| SCHEMBL7534301 | 0.67 | NOS1 (0.47) | NOS3NOS1NOS2MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1178784-A1 | NEW PHARMACEUTICAL COMBINATIONS FOR NOS INHIBITORS | Pfizer Products Inc. (US) | 2002-02-13 | — | — | EP | disclosed |
| WO-2000071107-A2 | NEW PHARMACEUTICAL COMBINATIONS FOR NOS INHIBITORS | PFIZER PRODUCTS INC. (US) | 2000-11-30 | — | — | WO | disclosed |