Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.38 |
| ▸ | VNN1 | O95497 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
| ▸ | XDH | P47989 | 1/20 | 0.37 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.37 |
| ▸ | NSD2 | O96028 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18316474 | 0.78 | CRHBP (0.44) | HSD11B1ALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL2234611 | 0.78 | CRHBP (0.44) | HSD11B1ALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL27475218 | 0.70 | HSD11B1 (0.44) | HSD11B1BACE1NOTUMALDH1A1CNR2 | |
| SCHEMBL3107917 | 0.69 | HCAR2 (0.72) | — | |
| Bicarbonate SCHEMBL11598627 | 0.68 | GSK3B (0.55) | NOTUMENPP2ALDH1A1GSK3BXDH | |
| SCHEMBL10083343 | 0.68 | HSD11B1 (0.50) | HSD11B1VNN1ALDH1A1CNR2GRIN2B | |
| SCHEMBL11833782 | 0.68 | CRHBP (0.41) | MEN1KMT2A | |
| SCHEMBL16954195 | 0.68 | HSD11B1 (0.42) | HSD11B1BACE1VNN1ALDH1A1CNR2 | |
| Bicarbonate SCHEMBL28730324 | 0.66 | GSK3B (0.53) | NOTUMENPP2ALDH1A1GSK3BXDH | |
| SCHEMBL29793755 | 0.66 | ICMT (0.43) | HSD11B1BACE1ENPP2NSD2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1189879-A1 | INHIBITORS OF FACTOR Xa | COR THERAPEUTICS, INC. (US) | 2002-03-27 | — | — | EP | disclosed |
| WO-2000071512-A1 | INHIBITORS OF FACTOR Xa | COR THERAPEUTICS, INC. (US) | 2000-11-30 | — | — | WO | disclosed |