Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | TP53 | P04637 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.53 |
| ▸ | RELA | Q04206 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 3/20 | 0.47 |
| ▸ | DRD4 | P21917 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | MMP14 | P50281 | 1/20 | 0.45 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4674022 | 0.80 | MAPT (0.50) | MAPTSMN1; SMN2KMT2ATP53GAA | |
| SCHEMBL28895576 | 0.76 | MEN1 (0.56) | MAPTSMN1; SMN2KMT2ATP53GAA | |
| SCHEMBL4673727 | 0.72 | MEN1 (0.52) | MAPTSMN1; SMN2KMT2ATP53GAA | |
| SCHEMBL4673723 | 0.72 | MEN1 (0.52) | MAPTSMN1; SMN2KMT2ATP53GAA | |
| SCHEMBL8096459 | 0.72 | MEN1 (0.49) | MAPTSMN1; SMN2KMT2ATP53GAA | |
| SCHEMBL4673636 | 0.71 | MMP14 (0.51) | MAPTSMN1; SMN2KMT2ATP53GAA | |
| SCHEMBL4673480 | 0.71 | MAPT (0.48) | MAPTSMN1; SMN2KMT2ATP53GAA | |
| SCHEMBL4673477 | 0.71 | MAPT (0.48) | MAPTSMN1; SMN2KMT2ATP53GAA | |
| SCHEMBL4677143 | 0.70 | SMN1; SMN2 (0.45) | MAPTSMN1; SMN2KMT2ATP53GAA | |
| SCHEMBL4677141 | 0.70 | SMN1; SMN2 (0.45) | MAPTSMN1; SMN2KMT2ATP53GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958287-A1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 1999-11-24 | — | — | EP | disclosed |
| WO-1998032748-A1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 1998-07-30 | — | — | WO | disclosed |