SCHEMBL4674022

SCHEMBL4674022

CC(C)(C)OC(=O)NS(=O)(=O)N1CCN(c2ccc(Cl)cc2)CC1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.50
TP53 P04637 1/20 0.50
HSD11B1 P28845 1/20 0.49
MEN1 O00255 2/20 0.49
KMT2A Q03164 2/20 0.49
SMN1; SMN2 Q16637 2/20 0.47
HTT P42858 2/20 0.47
NPSR1 Q6W5P4 2/20 0.47
MMP14 P50281 1/20 0.47
ADAMTS5 Q9UNA0 1/20 0.47
STS P08842 2/20 0.46
DRD4 P21917 2/20 0.44
DRD2 P14416 1/20 0.44
POLB P06746 1/20 0.43
GAA P10253 1/20 0.43
ALDH1A1 P00352 1/20 0.43
LMNA P02545 1/20 0.43
ALOX15 P16050 1/20 0.43
MAPK1 P28482 1/20 0.43
TDP1 Q9NUW8 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13940763 0.87 GPR119 (0.51) MAPTMEN1KMT2ASMN1; SMN2HTT
SCHEMBL7448674 0.80 MAPT (0.53) MAPTTP53MEN1KMT2ASMN1; SMN2
SCHEMBL28895576 0.79 MEN1 (0.56) MAPTTP53HSD11B1MEN1KMT2A
SCHEMBL20425001 0.75 ITGB3 (0.47) GPR119
SCHEMBL3936868 0.75 CA12 (0.41) SMN1; SMN2STSALDH1A1LMNAL3MBTL1
SCHEMBL8109659 0.75 MEN1 (0.52) MAPTTP53HSD11B1MEN1KMT2A
SCHEMBL583414 0.75 CA12 (0.42) GAAALDH1A1L3MBTL1
SCHEMBL12792779 0.75 CA12 (0.42) STSGAAL3MBTL1
SCHEMBL20430385 0.74 ALDH1A1 (0.43) MAPTMEN1KMT2ASMN1; SMN2GAA
SCHEMBL3108407 0.74 CNR1 (0.55) MAPTMEN1KMT2ASMN1; SMN2HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0958287-B2 SULFAMIDE-METALLOPROTEASE INHIBITORS HOFFMANN LA ROCHE (CH) 2008-04-09 EP disclosed
EP-0958287-B1 SULFAMIDE-METALLOPROTEASE INHIBITORS HOFFMANN LA ROCHE (CH) 2002-09-11 EP disclosed
US-6376506-B1 REACTING SULFAMOYL OXAZOLIDONE WITH (1,2,3,4)-TETRAHYDRO-BETA-CARBOLINE TO FORM INHIBITOR; USED TO TREAT ARTHRITIS, OSTEOPOROSIS, PERIODONTAL DISEASE, CARDIOVASCULAR DISEASES, MULTIPLE SCLEROSIS, AND TUMORS SYNTEX (U.S.A.) LLC 2002-04-23 US disclosed
US-6143744-A Sulfamide-metalloprotease inhibitors SYNTEX (U.S.A.) INC. (US) 2000-11-07 US disclosed
US-6130220-A ENZYME INHIBITORS SYNTEX (USA) INC. (US) 2000-10-10 US disclosed
US-5998412-A ANTIARTHRITIC AGENTS; OSTEOPOROSIS SYNTEX (U.S.A.) INC. (US) 1999-12-07 US disclosed
EP-0958287-A1 SULFAMIDE-METALLOPROTEASE INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 1999-11-24 EP disclosed
WO-1998032748-A1 SULFAMIDE-METALLOPROTEASE INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 1998-07-30 WO disclosed