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Sugi Predict / Compounds / Tyrosine

Tyrosine

Tyrosine

SCHEMBL7449350

CC(C)C[C@H](N)C(=O)O.CC(C)[C@H](N)C(=O)O.CC[C@H](C)[C@H](N)C(=O)O.C[C@H](N)C(=O)O.C[C@H](N)C(=O)O.NC(=O)C[C@H](N)C(=O)O.NC(=O)C[C@H](N)C(=O)O.NCC(=O)O.NCCCC[C@H](N)C(=O)O.NCCCC[C@H](N)C(=O)O.NCCCC[C@H](N)C(=O)O.N[C@@H](CCC(=O)O)C(=O)O.N[C@@H](Cc1c[nH]cn1)C(=O)O.N[C@@H](Cc1ccc(O)cc1)C(=O)O.N[C@@H](Cc1ccccc1)C(=O)O

nearest known ligand 0.36

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA

The experimentally established mechanism targets of Tyrosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ GLP1R P43220 14/20 0.36
▸ F2 P00734 4/20 0.36
▸ CRHR1 P34998 1/20 0.36
▸ CRHR2 Q13324 1/20 0.36
▸ VIPR1 P32241 1/20 0.35
▸ VIPR2 P41587 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phenylalanine SCHEMBL7449347 0.92 GLP1R (0.33) GLP1RF2CRHR1CRHR2
Phenylalanine SCHEMBL6241797 0.90 GLP1R (0.33) GLP1RF2CRHR1CRHR2VIPR1
Tyrosine SCHEMBL28529415 0.89 THRB (0.39) VIPR1VIPR2
Tyrosine SCHEMBL9357307 0.88 THRB (0.40) F2
Tyrosine SCHEMBL27801169 0.86 CALCR (0.35) GLP1RCRHR1CRHR2
Tyrosine SCHEMBL27636887 0.86 GLP1R (0.40) GLP1RVIPR1VIPR2
Tyrosine SCHEMBL29194960 0.86 GLP1R (0.38) GLP1RCRHR1CRHR2VIPR1VIPR2
Tyrosine SCHEMBL27651975 0.85 SLC7A5 (0.41) —
Arginine SCHEMBL10423273 0.85 GLP1R (0.37) GLP1RVIPR1VIPR2
Dl-Phenylalanine SCHEMBL27667772 0.85 THRB (0.34) GLP1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0812191-A4 AGLYCO PRODUCTS BOGOCH SAMUEL (US) 2002-07-24 — — EP claimed
EP-0812191-A1 AGLYCO PRODUCTS Bogoch, Samuel, Dr. (US) 1997-12-17 — — EP claimed
WO-1996032106-A1 AGLYCO PRODUCTS BOGOCH SAMUEL (US) 1996-10-17 — — WO claimed