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Sugi Predict / Compounds / Tyrosine

Tyrosine

Tyrosine

SCHEMBL9357307

CC(C)[C@H](N)C(=O)O.CC[C@H](C)[C@H](N)C(=O)O.CC[C@H](C)[C@H](N)C(=O)O.C[C@H](N)C(=O)O.NC(=O)C[C@H](N)C(=O)O.NC(=O)C[C@H](N)C(=O)O.NCCCC[C@H](N)C(=O)O.N[C@@H](CCC(=O)O)C(=O)O.N[C@@H](Cc1ccc(O)cc1)C(=O)O.N[C@@H](Cc1ccccc1)C(=O)O

nearest known ligand 0.40

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA

The experimentally established mechanism targets of Tyrosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ PTGS1 known ✓ P23219 1/20 0.35
▸ THRB P10828 1/20 0.40
▸ SLC7A5 Q01650 2/20 0.39
▸ F2 P00734 2/20 0.37
▸ MMP2 P08253 1/20 0.36
▸ ALPI P09923 1/20 0.35
▸ PKM P14618 1/20 0.35
▸ XIAP P98170 1/20 0.35
▸ ITGB3 P05106 1/20 0.35
▸ ITGA2B P08514 1/20 0.35
▸ ACE P12821 1/20 0.35
▸ OPRM1 P35372 2/20 0.34
▸ OPRD1 P41143 2/20 0.34
▸ BACE1 P56817 3/20 0.34
▸ KISS1R Q969F8 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tyrosine SCHEMBL10720159 0.93 SLC7A5 (0.44) THRBSLC7A5MMP2ALPIPKM
Tyrosine SCHEMBL10722619 0.93 SLC7A5 (0.44) THRBSLC7A5MMP2ALPIPKM
Tyrosine SCHEMBL28529415 0.92 THRB (0.39) THRBBACE1KISS1R
Tyrosine SCHEMBL7449350 0.88 GLP1R (0.36) F2
Tyrosine SCHEMBL10720154 0.87 THRB (0.41) THRBSLC7A5MMP2ALPIPKM
Arginine SCHEMBL19668411 0.87 THRB (0.38) THRBF2MMP2
Tyrosine SCHEMBL10722796 0.85 SLC7A5 (0.49) SLC7A5ALPIPKMPTGS1XIAP
Tyrosine SCHEMBL7624655 0.84 SLC7A5 (0.46) THRBSLC7A5MMP2ALPIPKM
Dl-Phenylalanine SCHEMBL28197596 0.84 THRB (0.46) THRBSLC7A5F2MMP2ALPI
Tyrosine SCHEMBL28066343 0.84 SLC7A5 (0.55) SLC7A5ALPIPKMPTGS1XIAP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0416816-B1 Hyposensitization agent HAYASHIBARA BIOCHEM LAB (JP) 1994-11-30 — — EP disclosed
US-5073628-A Desensitization, cedar pollinosis KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (JP) 1991-12-17 — — US disclosed