Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 7/20 | 0.89 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.89 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.89 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.89 |
| ▸ | TMPRSS6 | Q8IU80 | 2/20 | 0.89 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.89 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7442771 | 1.00 | F2 (0.89) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| SCHEMBL14543642 | 0.94 | F2 (1.00) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| Hydrochloric Acid SCHEMBL23541143 | 0.93 | F2 (1.00) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| Hydrochloric Acid SCHEMBL7091092 | 0.90 | F2 (0.76) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| SCHEMBL7450261 | 0.88 | F2 (0.72) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| SCHEMBL10922350 | 0.88 | F2 (0.86) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| SCHEMBL6629683 | 0.86 | F2 (0.83) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| SCHEMBL23566292 | 0.85 | PRSS1 (1.00) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| SCHEMBL7448763 | 0.84 | F2 (0.85) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| SCHEMBL7448742 | 0.84 | F2 (0.80) | F2PRSS1PRSS2PRSS3TMPRSS6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220096441-A1 | TREATMENT OF ACANTHAMOEBA OR BALAMUTHIA TROPHOZOITES AND/OR CYSTS | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2022-03-31 | — | — | US | disclosed |
| US-20210309641-A1 | AMIDINES AND AMIDINE ANALOGS FOR THE TREATMENT OF BACTERIAL INFECTIONS AND POTENTIATION ANTIBIOTICS | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2021-10-07 | — | — | US | disclosed |
| WO-2021127452-A1 | COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS AND POTENTIATION OF ANTIBIOTICS | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2021-06-24 | — | — | WO | disclosed |
| EP-1214291-A1 | BIPHENYL DERIVATIVES USED AS NHE-3 INHIBITORS | MERCK PATENT GmbH (DE) | 2002-06-19 | — | — | EP | disclosed |
| US-6380430-B1 | ANTICOAGULANTS | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTERHAFTUNG (DE) | 2002-04-30 | — | — | US | disclosed |
| WO-2001021582-A1 | BIPHENYL DERIVATIVES USED AS NHE-3 INHIBITORS | MERCK PATENT GMBH (DE) | 2001-03-29 | — | — | WO | disclosed |
| EP-1076643-A1 | BIPHENYL DERIVATIVES | MERCK PATENT GmbH (DE) | 2001-02-21 | — | — | EP | disclosed |
| WO-1999057096-A1 | BIPHENYL DERIVATIVES | MERCK PATENT GMBH (DE) | 1999-11-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210309641-A1 | AMIDINES AND AMIDINE ANALOGS FOR THE TREATMENT OF BACTERIAL INFECTIONS AND POTENTIATION ANTIBIOTICS | PAM, AMPD1, AMPD3 | F2 1488/4885PRSS1 652/4885PRSS2 1318/4885 |
| US-20220096441-A1 | TREATMENT OF ACANTHAMOEBA OR BALAMUTHIA TROPHOZOITES AND/OR CYSTS | PKD2, PKD1, MUC1 | F2 1185/4885PRSS1 2689/4885PRSS2 538/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.