Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | PLK4 | O00444 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | ROS1 | P08922 | 1/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.50 |
| ▸ | FLT1 | P17948 | 1/20 | 0.50 |
| ▸ | MARK3 | P27448 | 1/20 | 0.50 |
| ▸ | FLT4 | P35916 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | FLT3 | P36888 | 1/20 | 0.50 |
| ▸ | CLK2 | P49760 | 1/20 | 0.50 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.50 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.50 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7447991 | 0.88 | HPGD (0.47) | ATRHPGDRAB9AKDM4EALDH1A1 | |
| SCHEMBL7444528 | 0.80 | KDM4E (0.71) | HPGDMEN1KMT2ARAB9AKDM4E | |
| SCHEMBL17706589 | 0.79 | KDM4E (0.70) | ATRHPGDMEN1KMT2ARAB9A | |
| SCHEMBL18889251 | 0.79 | HRH4 (0.60) | HPGDMEN1KMT2ARAB9AKDM4E | |
| SCHEMBL7444669 | 0.77 | PARP1 (0.57) | HPGDFGFR1KDRALDH1A1L3MBTL1 | |
| SCHEMBL14091217 | 0.77 | ATR (0.49) | ATRMEN1KMT2AJAK2FGFR1 | |
| SCHEMBL8264513 | 0.76 | FGFR1 (0.55) | HPGDKMT2AJAK2FGFR1KDM4E | |
| SCHEMBL7491 | 0.75 | HPGD (0.71) | HPGDMEN1KMT2ARAB9AKDM4E | |
| SCHEMBL6124304 | 0.75 | NPC1 (0.61) | HPGDMEN1KMT2ARAB9AKDM4E | |
| SCHEMBL22955351 | 0.75 | MEN1 (0.59) | ATRHPGDMEN1KMT2AJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0968191-A1 | PHENYLBENZIMIDAZOLE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LTD. (GB) | 2000-01-05 | — | — | EP | claimed |
| WO-1998034923-A1 | PHENYLBENZIMIDAZOLE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 1998-08-13 | — | — | WO | claimed |
| EP-0968191-A1 | PHENYLBENZIMIDAZOLE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LTD. (GB) | 2000-01-05 | — | — | EP | disclosed |
| WO-1998034923-A1 | PHENYLBENZIMIDAZOLE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 1998-08-13 | — | — | WO | disclosed |