Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 2/20 | 0.57 |
| ▸ | HCRTR1 | O43613 | 5/20 | 0.53 |
| ▸ | HRH2 | P25021 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.44 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7324862 | 0.91 | CHEK2 (0.58) | CHEK2HCRTR1HRH2HRH1HCRTR2 | |
| SCHEMBL7399721 | 0.88 | CHEK2 (0.61) | CHEK2HCRTR1HRH2HRH1HCRTR2 | |
| SCHEMBL6615093 | 0.84 | HCRTR1 (0.58) | CHEK2HCRTR1HRH2HRH1HCRTR2 | |
| SCHEMBL6609250 | 0.84 | CHEK2 (0.56) | CHEK2HCRTR1HRH2HRH1HCRTR2 | |
| SCHEMBL7398730 | 0.84 | CHEK2 (0.57) | CHEK2HCRTR1HRH2HRH1HCRTR2 | |
| SCHEMBL6608981 | 0.84 | HCRTR1 (0.69) | CHEK2HCRTR1HCRTR2GPR119ALOX5AP | |
| SCHEMBL6535662 | 0.83 | ALOX5AP (0.57) | GPR119ALOX5APLTA4HALDH1A1 | |
| SCHEMBL2200111 | 0.83 | ALOX5AP (0.57) | GPR119ALOX5APLTA4HALDH1A1 | |
| SCHEMBL6536147 | 0.83 | ALOX5AP (0.57) | GPR119ALOX5APLTA4HALDH1A1 | |
| SCHEMBL4321825 | 0.82 | CHEK2 (0.56) | CHEK2HCRTR1HRH2HRH1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0763022-A1 | PHENOXYALKYL SUBSTITUTED PIPERIDINES, PYRROLIDINES, MORPHOLINES AND THIOMORPHOLINES AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1997-03-19 | — | — | EP | disclosed |
| WO-1995033723-A1 | PHENOXYALKYL SUBSTITUTED PIPERIDINES, PYRROLIDINES, MORPHOLINES AND THIOMORPHOLINES AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-12-14 | — | — | WO | disclosed |