Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | NAMPT | P43490 | 2/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | XBP1 | P17861 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.43 |
| ▸ | SDCBP | O00560 | 1/20 | 0.43 |
| ▸ | SDC2 | P34741 | 1/20 | 0.43 |
| ▸ | MTTP | P55157 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7447906 | 0.91 | NR1H4 (0.55) | NR1H4NPC1RAB9ANAMPTHDAC1 | |
| SCHEMBL7448308 | 0.87 | HDAC1 (0.52) | NAMPTHDAC1L3MBTL1SDCBPSDC2 | |
| SCHEMBL21523879 | 0.83 | NPC1 (0.64) | NR1H4NPC1RAB9ANAMPTHDAC1 | |
| SCHEMBL4687407 | 0.81 | CTSS (0.51) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL4687402 | 0.81 | CTSS (0.51) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL7452422 | 0.80 | CYP1A2 (0.45) | NR1H4NPC1RAB9ANAMPTHDAC1 | |
| SCHEMBL23775465 | 0.80 | ALDH1A1 (0.58) | NR1H4NPC1RAB9ANAMPTHDAC1 | |
| SCHEMBL7446916 | 0.79 | HDAC1 (0.50) | NAMPTHDAC1MAPTNPSR1L3MBTL1 | |
| SCHEMBL7457288 | 0.79 | HDAC1 (0.53) | NAMPTHDAC1L3MBTL1MEN1KMT2A | |
| SCHEMBL7446767 | 0.77 | HDAC1 (0.48) | NAMPTHDAC1ALDH1A1MAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001027096-A9 | AMINOMETHYL-(HETERO)ARYL DERIVATIVES AND THEIR USE AS TRYPTASE INHIBITORS | PROTHERICS MOLECULAR DESIGN LT (GB) | 2001-07-12 | — | — | WO | disclosed |