Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | AR | P10275 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3667525 | 0.79 | KMT2A (0.48) | ALDH1A1MAPK1LMNAHTTAR | |
| SCHEMBL3990234 | 0.78 | TDP1 (0.47) | ALDH1A1MAPK1LMNAHTTSMN1; SMN2 | |
| SCHEMBL8498625 | 0.78 | KMT2A (0.64) | ALDH1A1LMNAARKMT2AMEN1 | |
| SCHEMBL2559496 | 0.75 | RXFP1 (0.60) | ALDH1A1MAPK1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL2090122 | 0.73 | CA2 (0.57) | ALDH1A1 | |
| SCHEMBL1773322 | 0.73 | CMA1 (0.60) | ALDH1A1MAPK1LMNAHTTAR | |
| SCHEMBL28552779 | 0.72 | AR (0.54) | ALDH1A1ARSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL28550434 | 0.71 | AR (0.56) | ALDH1A1MAPK1LMNAHTTAR | |
| SCHEMBL22712813 | 0.70 | LTA4H (0.46) | — | |
| SCHEMBL25137282 | 0.69 | HDAC6 (0.56) | LMNAHTTARSMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001930-A2 | N-HYDROXYFORMAMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES | Abbott Laboratories (US) | 2000-05-24 | — | — | EP | disclosed |
| WO-1999006361-A2 | N-HYDROXYFORMAMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES | ABBOTT LABORATORIES (US) | 1999-02-11 | — | — | WO | disclosed |