Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 10/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 5/20 | 0.41 |
| ▸ | F10 | P00742 | 2/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.41 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.41 |
| ▸ | PLG | P00747 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7449809 | 0.90 | HSD11B1 (0.51) | HSD11B1MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL1464875 | 0.81 | AKR1C3 (0.41) | ALDH1A1CYP3A4CYP2C9CYP2C19HPGD | |
| SCHEMBL13373550 | 0.74 | HPGD (0.58) | HSD11B1MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL15386631 | 0.74 | ROCK2 (0.41) | ALDH1A1EPHX2 | |
| SCHEMBL435423 | 0.74 | ROCK2 (0.41) | ALDH1A1EPHX2 | |
| SCHEMBL1078190 | 0.73 | EPHX2 (0.34) | HSD11B1ALDH1A1HPGDEPHX2 | |
| SCHEMBL4664227 | 0.73 | EPHX2 (0.38) | HSD11B1MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL1855879 | 0.73 | HPGD (0.61) | HSD11B1MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL29565081 | 0.73 | HPGD (0.61) | HSD11B1MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL1855882 | 0.73 | HPGD (0.61) | HSD11B1MEN1KMT2AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1095025-A2 | BENZIMIDAZOLES, PRODUCTION THEREOF AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM KG (DE) | 2001-05-02 | — | — | EP | disclosed |
| WO-2000001704-A2 | BENZIMIDAZOLES, PRODUCTION THEREOF AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-01-13 | — | — | WO | disclosed |