Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 14/20 | 0.52 |
| ▸ | ITGAV | P06756 | 10/20 | 0.52 |
| ▸ | ITGB5 | P18084 | 7/20 | 0.52 |
| ▸ | ITGA2B | P08514 | 12/20 | 0.48 |
| ▸ | ITGB1 | P05556 | 6/20 | 0.43 |
| ▸ | ITGA5 | P08648 | 6/20 | 0.43 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.36 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | NPR3 | P17342 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7450342 | 0.93 | ITGB3 (0.55) | ITGB3ITGAVITGB5ITGA2BITGB1 | |
| SCHEMBL7448314 | 0.83 | ITGB3 (0.55) | ITGB3ITGAVITGB5ITGA2BITGB1 | |
| SCHEMBL7450849 | 0.80 | ITGB3 (0.55) | ITGB3ITGAVITGB5ITGA2BITGB1 | |
| SCHEMBL6492757 | 0.79 | ITGB3 (0.48) | ITGB3ITGAVITGB5ITGA2BITGB1 | |
| SCHEMBL6493323 | 0.79 | ITGB3 (0.48) | ITGB3ITGAVITGB5ITGA2BITGB1 | |
| SCHEMBL7452852 | 0.78 | ITGB3 (0.57) | ITGB3ITGAVITGB5ITGA2BITGB1 | |
| SCHEMBL6494656 | 0.78 | ITGB3 (0.44) | ITGB3ITGAVITGB5ITGA2BITGB1 | |
| SCHEMBL7444692 | 0.78 | ITGB3 (0.62) | ITGB3ITGAVITGB5ITGA2BITGB1 | |
| SCHEMBL7448307 | 0.77 | ITGB3 (0.58) | ITGB3ITGAVITGB5ITGA2BITGB1 | |
| SCHEMBL7451824 | 0.77 | ITGB3 (0.47) | ITGB3ITGAVITGB5ITGA2BITGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1187825-A1 | THIOPHENE INTEGRIN INHIBITORS | Shire Biochem Inc. (CA) | 2002-03-20 | — | — | EP | disclosed |
| US-6274620-B1 | 2-BENZENESULFONYLAMINO-3-((5-BROMO-THIOPHENE-2-CARBONYL)-AMINO )PROPIONIC ACID-TERT-BUTYL ESTERS AS ANGIOGENESIS INHIBITORS; ANTICARCINOGENIC AGENTS; OSTEOPOROSIS, RESTENOSIS, AND OCULAR NEOVASCULARIZATION | BIOCHEM PHARMA INC. (CA) | 2001-08-14 | — | — | US | disclosed |
| WO-2000075129-A1 | THIOPHENE INTEGRIN INHIBITORS | SHIRE BIOCHEM INC. (CA) | 2000-12-14 | — | — | WO | disclosed |