Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7450349 | 1.00 | HTT (0.31) | HTTKDM4EALDH1A1MAPTTDP1 | |
| SCHEMBL7451388 | 0.81 | HTT (0.39) | HTTKDM4EALDH1A1MAPTTDP1 | |
| SCHEMBL7451376 | 0.81 | HTT (0.39) | HTTKDM4EALDH1A1MAPTTDP1 | |
| SCHEMBL7454353 | 0.80 | NOX1 (0.35) | HTTKDM4EALDH1A1MAPTTDP1 | |
| SCHEMBL7453222 | 0.80 | NPC1 (0.35) | HTTKDM4EALDH1A1MAPTTDP1 | |
| SCHEMBL7451326 | 0.76 | ALDH1A1 (0.43) | HTTKDM4EALDH1A1MAPTTDP1 | |
| SCHEMBL7451322 | 0.76 | ALDH1A1 (0.43) | HTTKDM4EALDH1A1MAPTTDP1 | |
| SCHEMBL7451837 | 0.70 | MAOA (0.47) | HTTALDH1A1 | |
| SCHEMBL30954132 | 0.70 | MAOA (0.47) | HTTALDH1A1 | |
| SCHEMBL7450795 | 0.67 | ALDH1A1 (0.47) | ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011151361-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2011-12-08 | — | — | WO | disclosed |