Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 2/20 | 0.39 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27338142 | 0.91 | FFAR1 (0.45) | FFAR1CYP26A1LMNAMAPTMEN1 | |
| SCHEMBL7450364 | 0.81 | MAPT (0.43) | FFAR1LMNAMAPTMEN1KMT2A | |
| SCHEMBL9785916 | 0.76 | MEN1 (0.53) | MEN1KMT2ANPC1 | |
| SCHEMBL13194421 | 0.72 | LMNA (0.46) | LMNAMAPTMEN1KMT2ACYP2D6 | |
| SCHEMBL13240785 | 0.71 | LMNA (0.45) | LMNAMAPTMEN1KMT2ACYP2D6 | |
| SCHEMBL2483684 | 0.71 | LMNA (0.45) | LMNAMAPTMEN1KMT2ACYP2D6 | |
| SCHEMBL15645799 | 0.71 | MMP8 (0.50) | LMNAMAPTMEN1KMT2ACYP2D6 | |
| SCHEMBL5720974 | 0.70 | LMNA (0.39) | LMNAMAPTKMT2APOLBMAPK1 | |
| SCHEMBL5685475 | 0.70 | MAPT (0.55) | FFAR1LMNAMAPTMEN1KMT2A | |
| SCHEMBL27788467 | 0.70 | FFAR1 (0.46) | FFAR1CYP26A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1105389-A4 | INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2001-10-17 | — | — | EP | disclosed |
| EP-1105389-A1 | INTEGRIN RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2001-06-13 | — | — | EP | disclosed |
| US-6090944-A | Alkanoic acid derivatives as αv integrin receptor antagonists | MERCK & CO., INC. (US) | 2000-07-18 | — | — | US | disclosed |
| WO-2000009503-A1 | INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2000-02-24 | — | — | WO | disclosed |