Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 15/20 | 0.53 |
| ▸ | MMP1 | P03956 | 5/20 | 0.50 |
| ▸ | MMP3 | P08254 | 5/20 | 0.50 |
| ▸ | MMP2 | P08253 | 3/20 | 0.50 |
| ▸ | MMP9 | P14780 | 3/20 | 0.50 |
| ▸ | ADAM33 | Q9BZ11 | 3/20 | 0.50 |
| ▸ | MMP7 | P09237 | 1/20 | 0.49 |
| ▸ | MMP8 | P22894 | 1/20 | 0.49 |
| ▸ | MMP13 | P45452 | 1/20 | 0.49 |
| ▸ | MMP14 | P50281 | 1/20 | 0.49 |
| ▸ | MMP15 | P51511 | 1/20 | 0.49 |
| ▸ | MMP16 | P51512 | 1/20 | 0.49 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.49 |
| ▸ | ADAM9 | Q13443 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6600735 | 1.00 | ADAM17 (0.53) | ADAM17MMP1MMP3MMP2MMP9 | |
| SCHEMBL6597686 | 1.00 | ADAM17 (0.53) | ADAM17MMP1MMP3MMP2MMP9 | |
| SCHEMBL6597457 | 0.83 | ADAM17 (0.57) | ADAM17MMP2MMP9MMP13 | |
| SCHEMBL7404184 | 0.83 | ADAM17 (0.57) | ADAM17MMP2MMP9MMP13 | |
| SCHEMBL6597422 | 0.83 | ADAM17 (0.57) | ADAM17MMP2MMP9MMP13 | |
| Trifluoroacetic Acid SCHEMBL6600731 | 0.79 | ADAM17 (0.69) | ADAM17MMP1MMP3MMP2ADAM10 | |
| Trifluoroacetic Acid SCHEMBL6597682 | 0.79 | ADAM17 (0.69) | ADAM17MMP1MMP3MMP2ADAM10 | |
| SCHEMBL6598558 | 0.78 | ADAM17 (0.53) | ADAM17MMP2MMP9MMP13 | |
| SCHEMBL6597067 | 0.77 | MMP2 (0.55) | ADAM17MMP1MMP3MMP2MMP9 | |
| SCHEMBL6596662 | 0.77 | ADAM17 (0.51) | ADAM17MMP2MMP9MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1263756-A2 | BETA-AMINO ACID DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEASES AND TNF-ALPHA | Bristol-Myers Squibb Pharma Company (US) | 2002-12-11 | — | — | EP | disclosed |
| WO-2001070734-A2 | BETA-AMINO ACID DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEASES AND TNF-ALPHA | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2001-09-27 | — | — | WO | disclosed |