Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.36 |
| ▸ | NPC1 | O15118 | 5/20 | 0.36 |
| ▸ | TP53 | P04637 | 5/20 | 0.36 |
| ▸ | RAB9A | P51151 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 4/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CCR1 | P32246 | 1/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | CCR8 | P51685 | 1/20 | 0.34 |
| ▸ | METAP1 | P53582 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.34 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7449763 | 0.85 | CLK4 (0.33) | — | |
| SCHEMBL7446653 | 0.83 | RECQL (0.35) | ALDH1A1KDM4EPOLBHPGDHSD17B10 | |
| SCHEMBL9837227 | 0.77 | KDM4E (0.41) | SMN1; SMN2NPC1TP53RAB9AALDH1A1 | |
| SCHEMBL7144266 | 0.76 | SMN1; SMN2 (0.41) | PTK2SMN1; SMN2NPC1TP53RAB9A | |
| SCHEMBL7446479 | 0.74 | MAPT (0.35) | SMN1; SMN2NPC1TP53RAB9AALDH1A1 | |
| SCHEMBL20172587 | 0.72 | SMN1; SMN2 (0.52) | SMN1; SMN2NPC1TP53RAB9AALDH1A1 | |
| SCHEMBL559439 | 0.71 | — | — | |
| SCHEMBL558324 | 0.71 | ALDH1A1 (0.36) | NPC1TP53RAB9AALDH1A1MAPT | |
| SCHEMBL6054234 | 0.71 | MTOR (0.40) | SMN1; SMN2NPC1RAB9AALDH1A1MAPT | |
| SCHEMBL31660760 | 0.70 | JAK2 (0.42) | PTK2SMN1; SMN2NPC1TP53RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1104403-A1 | HYDROXY PIPECOLATE HYDROXAMIC ACID DERIVATIVES AS MMP INHIBITORS | Pfizer Products Inc. (US) | 2001-06-06 | — | — | EP | disclosed |
| WO-2000009485-A1 | HYDROXY PIPECOLATE HYDROXAMIC ACID DERIVATIVES AS MMP INHIBITORS | PFIZER PRODUCTS INC. (US) | 2000-02-24 | — | — | WO | disclosed |