Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.47 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.46 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.46 |
| ▸ | CTSK | P43235 | 14/20 | 0.42 |
| ▸ | CTSL | P07711 | 9/20 | 0.40 |
| ▸ | CTSS | P25774 | 5/20 | 0.40 |
| ▸ | CTSB | P07858 | 2/20 | 0.40 |
| ▸ | CTSV | O60911 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7453382 | 0.87 | TAS1R3 (0.46) | TRPV4TAS1R3TAS1R1CTSKCTSL | |
| SCHEMBL7446355 | 0.86 | TAS1R3 (0.46) | TRPV4TAS1R3TAS1R1CTSKCTSL | |
| SCHEMBL7453958 | 0.86 | CTSK (0.54) | TAS1R3TAS1R1CTSKCTSLCTSS | |
| SCHEMBL7450638 | 0.86 | CTSK (0.39) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL7453952 | 0.84 | CTSK (0.40) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL7445830 | 0.80 | HRH1 (0.35) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL7451430 | 0.79 | TAS1R3 (0.46) | TRPV4TAS1R3TAS1R1CTSKCTSL | |
| SCHEMBL7450632 | 0.77 | CTSK (0.51) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL7445866 | 0.76 | CTSK (0.47) | CTSKCTSLCTSSCTSB | |
| SCHEMBL7446343 | 0.75 | CTSK (0.60) | CTSKCTSLCTSSCTSBCTSV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140897-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2002-04-03 | — | — | EP | disclosed |
| EP-1140897-A1 | PROTEASE INHIBITORS | SmithKline Beecham Corporation (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000039115-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-07-06 | — | — | WO | disclosed |