Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | PPARG | P37231 | 5/20 | 0.40 |
| ▸ | PPARD | Q03181 | 2/20 | 0.40 |
| ▸ | PPARA | Q07869 | 2/20 | 0.40 |
| ▸ | MGLL | Q99685 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | NAAA | Q02083 | 2/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.34 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.34 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7450830 | 0.97 | CA2 (0.51) | CA2PPARGPPARDPPARAMGLL | |
| SCHEMBL11028560 | 0.79 | CA2 (0.43) | CA2PPARGPPARDPPARAALDH1A1 | |
| SCHEMBL11150673 | 0.72 | CA2 (0.56) | CA2PPARGPPARDPPARAALDH1A1 | |
| SCHEMBL7831230 | 0.72 | CA12 (0.40) | CA2MGLLALDH1A1NAAADDB1 | |
| SCHEMBL7257775 | 0.71 | CA2 (0.69) | CA2PPARGPPARDPPARAALDH1A1 | |
| SCHEMBL11793569 | 0.70 | CA2 (0.45) | CA2PPARGPPARDPPARAEPHX2 | |
| SCHEMBL8544891 | 0.69 | CA2 (0.67) | CA2PPARGPPARDPPARADDB1 | |
| SCHEMBL11147976 | 0.69 | CA2 (0.51) | CA2PPARGPPARDPPARA | |
| SCHEMBL31290248 | 0.68 | ALDH1A1 (0.41) | CA2MGLLALDH1A1TBXA2RPTGER1 | |
| SCHEMBL10688903 | 0.67 | CA2 (0.45) | CA2PPARGPPARDPPARADDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0804193-A4 | THIAZOLIDINE DERIVATIVES FOR THE TREATMENT OF PSORIASIS | KURTZ THEODORE W (US) | 2002-03-27 | — | — | EP | disclosed |
| US-6110951-A | LOWERING INSULIN DRUG THERAPY IN NON-OBESE, NON-DIABETIC INDIVIDUALS | BETHESDA PHARMACEUTICALS, INC. | 2000-08-29 | — | — | US | disclosed |
| US-5843970-A | Thiazolidine derivatives for the treatment of hypertension | BETHESDA PHARMACEUTICALS, INC. | 1998-12-01 | — | — | US | disclosed |
| US-5824694-A | Thiazolidine derivatives for the treatment of psoriasis | BETHESDA PHARMACEUTICALS, INC. (US) | 1998-10-20 | — | — | US | disclosed |
| EP-0804193-A1 | THIAZOLIDINE DERIVATIVES FOR THE TREATMENT OF PSORIASIS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1997-11-05 | — | — | EP | disclosed |
| US-5594015-A | Thiazolidine derivatives for the treatment of psoriasis | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1997-01-14 | — | — | US | disclosed |
| WO-1995035108-A1 | THIAZOLIDINE DERIVATIVES FOR THE TREATMENT OF PSORIASIS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1995-12-28 | — | — | WO | disclosed |
| US-5053420-A | Antidiabetic agents | KURTZ, THEODORE W. | 1991-10-01 | — | — | US | disclosed |
| WO-1991005538-A2 | THIAZOLIDINE DERIVATIVES FOR THE TREATMENT OF HYPERTENSION | PERSHADSINGH HARRIHAR A (US) | 1991-05-02 | — | — | WO | disclosed |
| EP-0091761-B1 | THIAZOLIDINE DERIVATIVES AND PRODUCTION THEREOF | Takeda Chemical Industries, Ltd. (JP) | 1987-11-19 | — | — | EP | disclosed |
| US-4486594-A | DIABETIC CATARACTS AND NEUROPATHY | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1984-12-04 | — | — | US | disclosed |
| EP-0091761-A2 | Thiazolidine derivatives and production thereof | Takeda Chemical Industries, Ltd. (JP) | 1983-10-19 | — | — | EP | disclosed |