Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CTSD | P07339 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 2/20 | 0.40 |
| ▸ | CES1 | P23141 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28245619 | 0.82 | SRC (0.52) | TDP1L3MBTL1SRCCYP2D6HDAC1 | |
| SCHEMBL7773819 | 0.82 | SRC (0.52) | TDP1L3MBTL1SRCCYP2D6HDAC1 | |
| SCHEMBL5609578 | 0.78 | EPHX1 (0.46) | TDP1L3MBTL1SRCCYP2D6HDAC1 | |
| SCHEMBL3237992 | 0.78 | TDP1 (0.43) | TDP1L3MBTL1SRCCYP2D6HDAC1 | |
| SCHEMBL9526813 | 0.77 | L3MBTL1 (0.63) | TDP1L3MBTL1SRCCYP2D6HDAC1 | |
| SCHEMBL3921899 | 0.77 | CTSD (0.39) | TDP1L3MBTL1SRCCYP2D6HDAC1 | |
| SCHEMBL5599310 | 0.77 | L3MBTL1 (0.63) | TDP1L3MBTL1SRCCYP2D6HDAC1 | |
| SCHEMBL1383207 | 0.77 | TDP1 (0.56) | TDP1L3MBTL1SRCCYP2D6HDAC1 | |
| SCHEMBL11341745 | 0.75 | HDAC3 (0.44) | TDP1L3MBTL1SRCCYP2D6HDAC1 | |
| SCHEMBL6596397 | 0.74 | CYP1A2 (0.50) | TDP1L3MBTL1SRCCYP2D6HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001087842-A1 | SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL PYRIDONES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE | PHARMACIA CORPORATION (US) | 2001-11-22 | — | — | WO | claimed |
| US-4992544-A | Intermediates for b-lactam antibiotics and b-lactamase inhibitor | UNIVERSITY OF NOTRE DAME DU LAC (US) | 1991-02-12 | — | — | US | disclosed |