Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 1/20 | 0.59 |
| ▸ | JAK2 | O60674 | 3/20 | 0.52 |
| ▸ | JAK1 | P23458 | 3/20 | 0.52 |
| ▸ | TYK2 | P29597 | 3/20 | 0.52 |
| ▸ | JAK3 | P52333 | 3/20 | 0.52 |
| ▸ | GABRP | O00591 | 1/20 | 0.51 |
| ▸ | GABRD | O14764 | 1/20 | 0.51 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.51 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.51 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.51 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.51 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.51 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.51 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.51 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.51 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.51 |
| ▸ | GABRE | P78334 | 1/20 | 0.51 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.51 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.51 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9074229 | 0.81 | HCAR3 (0.56) | HCAR3JAK2JAK1TYK2JAK3 | |
| SCHEMBL11264933 | 0.79 | KMT2A (0.55) | LMNAMEN1KMT2AAKR1B1PDE4B | |
| SCHEMBL23833540 | 0.78 | GABRP (0.61) | JAK2JAK1TYK2JAK3GABRP | |
| SCHEMBL30094658 | 0.78 | GABRP (0.61) | JAK2JAK1TYK2JAK3GABRP | |
| SCHEMBL152586 | 0.78 | HCAR3 (0.51) | HCAR3MAPTLMNAMEN1KMT2A | |
| SCHEMBL28056250 | 0.78 | HCAR3 (0.51) | HCAR3JAK2JAK1TYK2JAK3 | |
| SCHEMBL8545034 | 0.78 | HCAR3 (0.51) | HCAR3JAK2JAK1TYK2JAK3 | |
| SCHEMBL3981252 | 0.75 | PTK2 (0.56) | HCAR3JAK2JAK1TYK2JAK3 | |
| SCHEMBL71308 | 0.75 | HCAR3 (1.00) | HCAR3MAPTLMNAMEN1KMT2A | |
| SCHEMBL12462388 | 0.73 | HSD17B10 (0.60) | GABRPGABRDGABRA1GABRB1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242076-A4 | 2-BENZYL AND 2-HETEROARYL BENZIMIDAZOLE NMDA/NR2B ANTAGONISTS | MERCK & CO INC (US) | 2002-11-27 | — | — | EP | disclosed |
| EP-1242076-A1 | 2-BENZYL AND 2-HETEROARYL BENZIMIDAZOLE NMDA/NR2B ANTAGONISTS | Merck & Co., Inc. (US) | 2002-09-25 | — | — | EP | disclosed |
| US-6316474-B1 | TREATMENT OF PAIN, SCHIZOPHRENIA, PARKINSON'S DISEASE, STROKE AND DEPRESSION | MERCK & CO., INC. | 2001-11-13 | — | — | US | disclosed |
| WO-2001032174-A1 | 2-BENZYL AND 2-HETEROARYL BENZIMIDAZOLE NMDA/NR2B ANTAGONISTS | MERCK & CO., INC. (US) | 2001-05-10 | — | — | WO | disclosed |