Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.33 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 4/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | RAD52 | P43351 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | IDE | P14735 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6297873 | 0.68 | BCHE (0.35) | KMT2AALDH1A1BCHEOPRM1SMN1; SMN2 | |
| SCHEMBL7451547 | 0.65 | ALDH1A1 (0.36) | KMT2APRKCZKDM4EALDH1A1MEN1 | |
| SCHEMBL10258086 | 0.63 | ALDH1A1 (0.58) | KMT2ANPSR1MAPTKDM4EALDH1A1 | |
| SCHEMBL7447329 | 0.60 | HTT (0.39) | MAPTLMNATP53HTT | |
| SCHEMBL7447344 | 0.60 | TRPV1 (0.39) | ALDH1A1SMN1; SMN2TP53HTT | |
| SCHEMBL8312931 | 0.59 | SLC6A9 (0.34) | MAPTKDM4EALDH1A1BCHELMNA | |
| SCHEMBL8311281 | 0.56 | ALDH1A1 (0.33) | MAPTKDM4EALDH1A1BCHE | |
| SCHEMBL7456043 | 0.56 | ATM (0.39) | KDM4EARLMNA | |
| SCHEMBL10258566 | 0.56 | CES2 (0.53) | KMT2ANPSR1MAPTKDM4EALDH1A1 | |
| SCHEMBL6847655 | 0.54 | GSK3B (0.54) | KMT2ANPSR1MAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165557-A1 | ARYL AND HETEROARYL FUSED AMINOALKYL-IMIDAZOLE DERIVATIVES: SELECTIVE MODULATORS OF GABAa RECEPTORS | NEUROGEN CORPORATION (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059905-A1 | ARYL AND HETEROARYL FUSED AMINOALKYL-IMIDAZOLE DERIVATIVES: SELECTIVE MODULATORS OF GABAa RECEPTORS | NEUROGEN CORPORATION (US) | 2000-10-12 | — | — | WO | disclosed |