SCHEMBL7452913

SCHEMBL7452913

N#Cc1cccc(OCc2cccc(-c3cccc(C#N)c3)c2)c1

nearest known ligand 0.56

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
GABRG2 P18507 2/20 0.56
GABRB3 P28472 2/20 0.56
GABRA5 P31644 2/20 0.56
GABRA3 P34903 2/20 0.56
F2 P00734 2/20 0.54
NR4A2 P43354 1/20 0.54
FFAR1 O14842 2/20 0.52
FFAR4 Q5NUL3 1/20 0.52
MAOB P27338 5/20 0.50
MAOA P21397 2/20 0.50
GPR34 Q9UPC5 1/20 0.50
PDCD1 Q15116 1/20 0.49
CD274 Q9NZQ7 1/20 0.49
MRGPRX4 Q96LA9 2/20 0.49
GRM5 P41594 1/20 0.48
CYP4F2 P78329 1/20 0.46
CYP4A11 Q02928 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7451938 0.94 GABRG2 (0.56) GABRG2GABRB3GABRA5GABRA3F2
SCHEMBL25232686 0.90 NR4A2 (0.60) GABRG2GABRB3GABRA5GABRA3F2
SCHEMBL30406905 0.90 NR4A2 (0.60) GABRG2GABRB3GABRA5GABRA3F2
SCHEMBL1171578 0.89 GABRG2 (0.66) GABRG2GABRB3GABRA5GABRA3NR4A2
SCHEMBL30344886 0.85 MAOB (0.69) GABRG2GABRB3GABRA5GABRA3NR4A2
SCHEMBL538272 0.85 MAOB (0.69) GABRG2GABRB3GABRA5GABRA3NR4A2
SCHEMBL1248693 0.83 MAOB (0.66) GABRG2GABRB3GABRA5GABRA3FFAR1
SCHEMBL3900543 0.83 MAOB (0.59) F2FFAR1FFAR4MAOBMAOA
SCHEMBL23235763 0.83 MAOB (0.63) FFAR1FFAR4MAOBMAOAMRGPRX4
SCHEMBL1249009 0.83 GPR34 (0.58) GABRG2GABRB3GABRA5GABRA3NR4A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1214291-A1 BIPHENYL DERIVATIVES USED AS NHE-3 INHIBITORS MERCK PATENT GmbH (DE) 2002-06-19 EP disclosed
US-6380430-B1 ANTICOAGULANTS MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTERHAFTUNG (DE) 2002-04-30 US disclosed
WO-2001021582-A1 BIPHENYL DERIVATIVES USED AS NHE-3 INHIBITORS MERCK PATENT GMBH (DE) 2001-03-29 WO disclosed
EP-1076643-A1 BIPHENYL DERIVATIVES MERCK PATENT GmbH (DE) 2001-02-21 EP disclosed
WO-1999057096-A1 BIPHENYL DERIVATIVES MERCK PATENT GMBH (DE) 1999-11-11 WO disclosed