Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP7 | P09237 | 1/20 | 0.63 |
| ▸ | MMP13 | P45452 | 4/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.48 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.36 |
| ▸ | MMP14 | P50281 | 3/20 | 0.35 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 2/20 | 0.34 |
| ▸ | RORC | P51449 | 2/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7451418 | 0.88 | MMP7 (0.48) | MMP7MMP13CYP3A4KDM4EALDH1A1 | |
| SCHEMBL6646114 | 0.85 | MMP7 (0.46) | MMP7MMP13CYP3A4KDM4EALDH1A1 | |
| SCHEMBL6648538 | 0.82 | MMP7 (0.44) | MMP7MMP13CYP3A4KDM4EALDH1A1 | |
| SCHEMBL6650057 | 0.79 | MMP7 (0.40) | MMP7MMP13CYP3A4KDM4EALDH1A1 | |
| SCHEMBL5883512 | 0.77 | MMP7 (1.00) | MMP7MMP13CYP3A4CXCR3KDM4E | |
| SCHEMBL5883894 | 0.77 | MMP7 (1.00) | MMP7MMP13CYP3A4CXCR3KDM4E | |
| SCHEMBL6645193 | 0.77 | MMP7 (0.38) | MMP7MMP13CYP3A4KDM4EALDH1A1 | |
| SCHEMBL7456863 | 0.75 | ADAMTS4 (0.46) | MMP7MMP13CYP3A4MMP14ADAMTS4 | |
| SCHEMBL5883959 | 0.75 | MMP7 (0.83) | MMP7MMP13CYP3A4CXCR3KDM4E | |
| SCHEMBL7363493 | 0.74 | KDM4E (0.52) | MMP7MMP13CYP3A4KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1261590-A1 | PIPERIDINE- AND PIPERAZINE SUBSTITUTED N-HYDROXYFORMAMIDES AS INHIBITORS OF METALLOPROTEINASES | AstraZeneca AB (SE) | 2002-12-04 | — | — | EP | disclosed |
| WO-2001062742-A1 | PIPERIDINE- AND PIPERAZINE SUBSTITUTED N-HYDROXYFORMAMIDES AS INHIBITORS OF METALLOPROTEINASES | ASTRAZENECA AB (SE) | 2001-08-30 | — | — | WO | disclosed |