Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MMP7 | P09237 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | CTSS | P25774 | 4/20 | 0.42 |
| ▸ | F13A1 | P00488 | 1/20 | 0.41 |
| ▸ | TGM2 | P21980 | 1/20 | 0.41 |
| ▸ | TGM1 | P22735 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7360833 | 0.77 | MMP7 (0.46) | KDM4EALDH1A1MAPTHSD17B10MMP7 | |
| SCHEMBL12463849 | 0.76 | MMP7 (0.61) | KDM4EALDH1A1MAPTHSD17B10MMP7 | |
| SCHEMBL12463845 | 0.76 | KDM4E (0.56) | KDM4EALDH1A1MAPTHSD17B10MMP7 | |
| SCHEMBL7358595 | 0.75 | MMP7 (0.38) | KDM4EALDH1A1MAPTHSD17B10MMP7 | |
| SCHEMBL2156392 | 0.75 | KDM4E (0.55) | KDM4EALDH1A1MAPTHSD17B10MMP7 | |
| SCHEMBL4816679 | 0.74 | MMP7 (0.61) | KDM4EALDH1A1MAPTHSD17B10MMP7 | |
| SCHEMBL14252763 | 0.74 | MMP7 (0.61) | KDM4EALDH1A1MAPTHSD17B10MMP7 | |
| SCHEMBL5504337 | 0.74 | KDM4E (0.57) | KDM4EALDH1A1MAPTHSD17B10MMP7 | |
| SCHEMBL7453091 | 0.74 | MMP7 (0.63) | KDM4EALDH1A1MAPTHSD17B10MMP7 | |
| SCHEMBL2155256 | 0.72 | KDM4E (0.55) | KDM4EALDH1A1MAPTHSD17B10MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109787-A1 | ARYLPIPERAZINES AND THEIR USE AS METALLOPROTEINASE INHIBITING AGENTS (MMP) | AstraZeneca AB (SE) | 2001-06-27 | — | — | EP | disclosed |
| WO-2000012478-A1 | ARYLPIPERAZINES AND THEIR USE AS METALLOPROTEINASE INHIBITING AGENTS (MMP) | ASTRAZENECA AB (SE) | 2000-03-09 | — | — | WO | disclosed |