Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.47 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7456883 | 0.90 | ALDH1A1 (0.53) | SMN1; SMN2ALDH1A1TDP1CYP1A2CYP3A4 | |
| SCHEMBL7458969 | 0.88 | MAPT (0.49) | SMN1; SMN2ALDH1A1TDP1CYP1A2CYP3A4 | |
| SCHEMBL7462906 | 0.87 | MAPT (0.51) | SMN1; SMN2ALDH1A1TDP1CYP1A2CYP3A4 | |
| SCHEMBL7460357 | 0.86 | L3MBTL1 (0.49) | SMN1; SMN2ALDH1A1TDP1CYP1A2CYP3A4 | |
| SCHEMBL7463833 | 0.83 | PRMT5 (0.55) | SMN1; SMN2ALDH1A1TDP1CYP1A2CYP3A4 | |
| SCHEMBL7459783 | 0.79 | ALDH1A1 (0.53) | SMN1; SMN2ALDH1A1TDP1CYP1A2CYP3A4 | |
| SCHEMBL7461619 | 0.78 | ALDH1A1 (0.52) | SMN1; SMN2ALDH1A1TDP1CYP1A2CYP3A4 | |
| SCHEMBL7462894 | 0.78 | KDM4E (0.64) | SMN1; SMN2ALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL7467237 | 0.77 | KDM4E (0.52) | SMN1; SMN2ALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL1702460 | 0.77 | KMT2A (0.55) | SMN1; SMN2ALDH1A1TDP1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0869122-B1 | Quinolinic sulfide derivatives acting as NMDA receptor antagonists and process for preparation thereof | KOREA RES INST CHEM TECH (KR) | 2002-12-04 | — | — | EP | disclosed |
| US-5990126-A | 4-HYDROXY-QUINOLIN-2-ONE DERIVATIVES SUBSTITUTED AT POSITION 3 WITH A SUBSTITUTED AROMATIC- OR HETEROAROMATIC-SULFIDE GROUP; ANTAGONIST OF EXCITATORY AMINO ACID FOR NMDA RECEPTORS; TREATING EPILEPSY, STROKE, PARKINSON'S DISEASE | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 1999-11-23 | — | — | US | disclosed |
| EP-0869122-A1 | Quinolinic sulfide derivatives acting as NMDA receptor antagonists and process for preparation thereof | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 1998-10-07 | — | — | EP | disclosed |