Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 4/20 | 0.38 |
| ▸ | BRD4 | O60885 | 3/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7453292 | 0.81 | CREBBP (0.46) | TP53TSHRCREBBPBRD4ALDH1A1 | |
| SCHEMBL7512566 | 0.76 | KMT2A (0.43) | ALDH1A1GAARAB9A | |
| SCHEMBL9745679 | 0.76 | KMT2A (0.43) | ALDH1A1GAARAB9A | |
| SCHEMBL7449138 | 0.76 | KMT2A (0.43) | ALDH1A1GAARAB9A | |
| SCHEMBL7326324 | 0.75 | ITGB1 (0.42) | NPSR1CREBBPBRD4ALDH1A1 | |
| SCHEMBL7326331 | 0.75 | ITGB1 (0.42) | NPSR1CREBBPBRD4ALDH1A1 | |
| SCHEMBL21121174 | 0.68 | LMNA (0.49) | NPSR1CREBBPBRD4GAASMN1; SMN2 | |
| SCHEMBL21121173 | 0.68 | LMNA (0.49) | NPSR1CREBBPBRD4GAASMN1; SMN2 | |
| SCHEMBL6768435 | 0.67 | NPSR1 (0.57) | TSHRNPSR1ALDH1A1GAASMN1; SMN2 | |
| SCHEMBL22559986 | 0.66 | CTSD (0.44) | CREBBPBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140821-A1 | LACTAMS | ISIS INNOVATION LIMITED (GB) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035871-A1 | LACTAMS | ISIS INNOVATION LIMITED (GB) | 2000-06-22 | — | — | WO | disclosed |