Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 5/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.53 |
| ▸ | HTR3A | P46098 | 2/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.37 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.35 |
| ▸ | HTR3B | O95264 | 1/20 | 0.35 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.35 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | KMO | O15229 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL745399 | 1.00 | CHRNA7 (0.53) | CHRNA7KCNH2HTR3ACHRNB2CHRNA4 | |
| Trifluoroacetic Acid SCHEMBL745211 | 0.91 | CHRNA7 (0.45) | CHRNA7KCNH2HTR3ACHRNB2CHRNA4 | |
| Trifluoroacetic Acid SCHEMBL990616 | 0.91 | CHRNA7 (0.45) | CHRNA7KCNH2HTR3ACHRNB2CHRNA4 | |
| SCHEMBL746896 | 0.82 | CHRNA7 (0.48) | CHRNA7KCNH2HTR3ACHRNB2CHRNA4 | |
| SCHEMBL747523 | 0.82 | CHRNA7 (0.48) | CHRNA7KCNH2HTR3ACHRNB2CHRNA4 | |
| SCHEMBL745277 | 0.81 | CHRNA7 (0.61) | CHRNA7KCNH2HTR3ACHRNB2CHRNA4 | |
| SCHEMBL745674 | 0.80 | CHRNA7 (0.40) | CHRNA7SLC6A2SLC6A3HTT | |
| SCHEMBL745145 | 0.79 | CHRNA7 (0.52) | CHRNA7KCNH2CHRNB2CHRNA4SLC6A2 | |
| SCHEMBL745762 | 0.79 | CHRNA7 (0.53) | CHRNA7KCNH2SLC6A2SLC6A3DYRK1A | |
| SCHEMBL745763 | 0.79 | CHRNA7 (0.53) | CHRNA7KCNH2SLC6A2SLC6A3DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2431368-A1 | CNS active fused bicycloheterocycle substituted azabicyclic alkane derivatives | Abbott Laboratories (US) | 2012-03-21 | — | — | EP | claimed |
| EP-2018380-B1 | Cns active fused bicycloheterocycle substituted azabicyclic alkane derivatives | ABBOTT LAB (US) | 2011-10-19 | — | — | EP | claimed |
| US-20100305089-A1 | Fused Bicycloheterocycle Substituted Azabicyclic Alkane Derivatives | ABBOTT LABORATORIES (US) | 2010-12-02 | — | — | US | claimed |
| US-20080045539-A1 | FUSED BICYCLOHETEROCYCLE SUBSTITUTED AZABICYCLIC ALKANE DERIVATIVES | ABBVIE INC. | 2008-02-21 | — | — | US | claimed |
| US-8940762-B2 | Methods for treating pain | ABBVIE INC. (US) | 2015-01-27 | — | — | US | disclosed |
| EP-2431368-B1 | CNS active fused bicycloheterocycle substituted azabicyclic alkane derivatives | ABBVIE BAHAMAS LTD (BS) | 2014-08-27 | — | — | EP | disclosed |
| EP-2431368-A1 | CNS active fused bicycloheterocycle substituted azabicyclic alkane derivatives | Abbott Laboratories (US) | 2012-03-21 | — | — | EP | disclosed |
| US-20110178121-A1 | Methods for Treating Pain | ABBOTT LABORATORIES (US) | 2011-07-21 | — | — | US | disclosed |
| US-7872017-B2 | Fused bicycloheterocycle substituted azabicyclic alkane derivatives | ABBOTT LABORATORIES (US) | 2011-01-18 | — | — | US | disclosed |
| US-20100305089-A1 | Fused Bicycloheterocycle Substituted Azabicyclic Alkane Derivatives | ABBOTT LABORATORIES (US) | 2010-12-02 | — | — | US | disclosed |
| US-20080045539-A1 | FUSED BICYCLOHETEROCYCLE SUBSTITUTED AZABICYCLIC ALKANE DERIVATIVES | ABBVIE INC. | 2008-02-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080045539-A1 | FUSED BICYCLOHETEROCYCLE SUBSTITUTED AZABICYCLIC ALKANE DERIVATIVES | MALT1, BMP2, ALKBH2 | CHRNA7 2776/4885KCNH2 708/4885HTR3A 2305/4885 |
| US-20100305089-A1 | Fused Bicycloheterocycle Substituted Azabicyclic Alkane Derivatives | MALT1, BMP2, ALKBH2 | CHRNA7 2776/4885KCNH2 708/4885HTR3A 2305/4885 |
| US-20110178121-A1 | Methods for Treating Pain | CHRNA7, CHRNA3, CHRNA5 | CHRNA7 1/4885KCNH2 183/4885HTR3A 289/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.