Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.71 |
| ▸ | SMARCA2 | P51531 | 6/20 | 0.37 |
| ▸ | SMARCA4 | P51532 | 5/20 | 0.37 |
| ▸ | MET | P08581 | 6/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CD38 | P28907 | 1/20 | 0.36 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7458646 | 0.88 | GRM5 (0.73) | GRM5SMARCA2SMARCA4NPC1MAPT | |
| SCHEMBL7459153 | 0.86 | GRM5 (0.72) | GRM5SMARCA2SMARCA4MAPTCSNK1E | |
| SCHEMBL7453851 | 0.86 | GRM5 (0.69) | GRM5SMARCA2SMARCA4KDM4ENPC1 | |
| SCHEMBL7454592 | 0.85 | GRM5 (0.68) | GRM5SMARCA2SMARCA4METNPC1 | |
| SCHEMBL7445410 | 0.83 | GRM5 (1.00) | GRM5SMARCA2SMARCA4METKDM4E | |
| SCHEMBL7451577 | 0.82 | GRM5 (0.55) | GRM5SMARCA2SMARCA4METKDM4E | |
| SCHEMBL7560379 | 0.81 | GRM5 (0.59) | GRM5SMARCA2SMARCA4METKDM4E | |
| SCHEMBL7454077 | 0.77 | GRM5 (0.58) | GRM5SMARCA2SMARCA4METNPC1 | |
| SCHEMBL7458429 | 0.77 | GRM5 (0.61) | GRM5SMARCA2SMARCA4MAPTMEN1 | |
| SCHEMBL7453711 | 0.77 | GRM5 (0.58) | GRM5SMARCA2SMARCA4KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011151361-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2011-12-08 | — | — | WO | disclosed |
| WO-2011151361-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2011-12-08 | — | — | WO | disclosed |