Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 7/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 2/20 | 0.38 |
| ▸ | SORT1 | Q99523 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.36 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.36 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7458646 | 0.90 | GRM5 (0.73) | GRM5MAPTSMN1; SMN2NPC1LMNA | |
| SCHEMBL7458429 | 0.89 | GRM5 (0.61) | GRM5MAPTSORT1MEN1KMT2A | |
| SCHEMBL7449344 | 0.87 | GRM5 (0.54) | GRM5MAPTSMN1; SMN2NPC1LMNA | |
| SCHEMBL7458050 | 0.83 | GRM5 (0.48) | GRM5SORT1MEN1KMT2AHSD17B3 | |
| SCHEMBL7453711 | 0.83 | GRM5 (0.58) | GRM5SMN1; SMN2NPC1LMNARAB9A | |
| SCHEMBL7459153 | 0.80 | GRM5 (0.72) | GRM5MAPTMEN1KMT2AHSD17B3 | |
| SCHEMBL7454043 | 0.77 | GRM5 (0.71) | GRM5MAPTNPC1RAB9AMET | |
| SCHEMBL7454592 | 0.77 | GRM5 (0.68) | GRM5MAPTSMN1; SMN2NPC1LMNA | |
| SCHEMBL7453223 | 0.76 | GABRG2 (0.45) | SMN1; SMN2LMNATP53MEN1KMT2A | |
| SCHEMBL3405011 | 0.75 | MET (0.59) | GRM5MAPTSMN1; SMN2NPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011151361-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2011-12-08 | — | — | WO | disclosed |
| WO-2011151361-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2011-12-08 | — | — | WO | disclosed |