Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 6/20 | 0.65 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.65 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.65 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.65 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.65 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | BRD4 | O60885 | 5/20 | 0.61 |
| ▸ | BRD2 | P25440 | 2/20 | 0.61 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.61 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.61 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7464482 | 0.86 | PDE4A (0.86) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL7454900 | 0.85 | SMN1; SMN2 (0.61) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL516463 | 0.84 | PDE4A (0.81) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL7031729 | 0.84 | MEN1 (0.87) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL11462282 | 0.81 | PDE4A (0.64) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL7454403 | 0.80 | PDE4A (0.61) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL27600173 | 0.80 | BRD4 (0.70) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL556875 | 0.79 | BRD4 (0.65) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL3902928 | 0.79 | PDE4A (1.00) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL12257284 | 0.79 | PDE4A (0.80) | PDE4AADORA2APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0570831-A2 | Use of Xanthinderivatives for treatment of cerebral nerve dammages after disruption of the blood circulation | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-11-24 | — | — | EP | disclosed |