Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C | P18825 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | TOP2A | P11388 | 1/20 | 0.37 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | XBP1 | P17861 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7786053 | 1.00 | ADRA2C (0.50) | ADRA2CTP53LMNAHTTKCNH2 | |
| SCHEMBL30514270 | 1.00 | ADRA2C (0.50) | ADRA2CTP53LMNAHTTKCNH2 | |
| SCHEMBL7783863 | 0.82 | TSHR (0.36) | ADRA2CLMNAHTTTSHRMAPT | |
| SCHEMBL11452909 | 0.82 | ADRA2C (0.51) | ADRA2CTP53LMNAHTTKCNH2 | |
| SCHEMBL7460986 | 0.82 | ADRA2C (0.51) | ADRA2CTP53LMNAHTTKCNH2 | |
| SCHEMBL3124491 | 0.82 | ADRA2C (0.51) | ADRA2CTP53LMNAHTTKCNH2 | |
| SCHEMBL7453698 | 0.82 | ADRA2C (0.51) | ADRA2CTP53LMNAHTTKCNH2 | |
| SCHEMBL6212874 | 0.82 | ADRA2C (0.51) | ADRA2CTP53LMNAHTTKCNH2 | |
| SCHEMBL10396657 | 0.82 | LMNA (0.53) | ADRA2CTP53LMNAHTTKCNH2 | |
| SCHEMBL29845931 | 0.82 | ADRA2C (0.51) | ADRA2CTP53LMNAHTTKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017108972-A1 | COMPOUNDS OF R-(-)-(E)-[4-(2,4-DICHLOROPHENYL)-1,3-DITHIOLAN-2-YLIDENE]-1 -IMIDAZOLYLACETONITRILE-HA (LULICONAZOLE-HA) AS ANTIFUNGALS | LABORATORIOS LESVI, S.L. (ES) | 2017-06-29 | — | — | WO | disclosed |
| WO-2017108972-A1 | COMPOUNDS OF R-(-)-(E)-[4-(2,4-DICHLOROPHENYL)-1,3-DITHIOLAN-2-YLIDENE]-1 -IMIDAZOLYLACETONITRILE-HA (LULICONAZOLE-HA) AS ANTIFUNGALS | LABORATORIOS LESVI, S.L. (ES) | 2017-06-29 | — | — | WO | disclosed |
| CN-106008166-A | Industrialized production method of chiral 2- chloro-1-(2,4-dichlorophenyl) ethanol | 上海福乐医药科技有限公司 | 2016-10-12 | — | — | CN | disclosed |
| EP-0839035-B1 | ANTIFUNGAL AGENT, COMPOUND THEREFOR, PROCESS FOR PRODUCING THE SAME | NIHON NOHYAKU CO LTD (JP) | 2002-10-02 | — | — | EP | disclosed |
| US-5900488-A | Method for treating mycosis using imidazolylacetonitrile derivatives | NIHON NOHYAKU CO., LTD. (JP) | 1999-05-04 | — | — | US | disclosed |
| EP-0839035-A2 | ANTIFUNGAL AGENT, COMPOUND THEREFOR, PROCESS FOR PRODUCING THE SAME | Nihon Nohyaku Co., Ltd. (JP) | 1998-05-06 | — | — | EP | disclosed |
| WO-1997002821-A2 | ANTIFUNGAL AGENT, COMPOUND THEREFOR, PROCESS FOR PRODUCING THE SAME | NIHON NOHYAKU CO., LTD. (JP) | 1997-01-30 | — | — | WO | disclosed |