SCHEMBL7783863

SCHEMBL7783863

OC(CBr)c1ccc(Br)cc1Cl

nearest known ligand 0.42

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.36
ADRA2C P18825 1/20 0.36
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
MAPK1 P28482 1/20 0.35
ALDH1A1 P00352 4/20 0.33
ESR1 P03372 1/20 0.33
IGF1R P08069 1/20 0.33
LMNA P02545 1/20 0.33
HTT P42858 1/20 0.33
PDE2A O00408 1/20 0.33
GAA P10253 1/20 0.32
MAPT P10636 1/20 0.32
RECQL P46063 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7787266 0.83 LMNA (0.37) ADRA2CLMNAPDE2AMAPT
SCHEMBL7786053 0.82 ADRA2C (0.50) TSHRADRA2CKMT2AMAPK1LMNA
SCHEMBL7455141 0.82 ADRA2C (0.50) TSHRADRA2CKMT2AMAPK1LMNA
SCHEMBL30514270 0.82 ADRA2C (0.50) TSHRADRA2CKMT2AMAPK1LMNA
SCHEMBL7786042 0.79 MDM2 (0.39) ADRA2CPDE2A
SCHEMBL21404173 0.79 ADRB2 (0.37) TSHRADRA2CMEN1KMT2AMAPK1
SCHEMBL30632035 0.79 ADRB2 (0.37) TSHRADRA2CMEN1KMT2AMAPK1
SCHEMBL20054190 0.77 CA1 (0.33) MEN1KMT2AALDH1A1IGF1RGAA
SCHEMBL2698362 0.76 PDE2A (0.55) TSHRMEN1KMT2AMAPK1ALDH1A1
SCHEMBL9910111 0.76 PDE2A (0.55) TSHRMEN1KMT2AMAPK1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0735142-B1 Process for producing (R)-styrene oxides SUMIKA FINE CHEMICALS CO LTD (JP) 2001-10-24 EP disclosed
US-6156940-A Process for producing optically active carbinols SUMIKA FINE CHEMICALS COMPANY, LIMITED (JP) 2000-12-05 US disclosed
EP-0713848-B1 Process for producing optically active carbinols SUMIKA FINE CHEMICALS COMPANY (JP) 1999-09-08 EP disclosed
US-5831132-A REDUCING AGENT FROM BORANES AND AMINO ALCOHOLS SUMIKA FINE CHEMICALS COMPANY, LTD. (JP) 1998-11-03 US disclosed
US-5717116-A TREATING A MIXTURE OF PHENYLHALOGENOMETHYLCARBINOLS WITH A LIPASE IN THE PRESENCE OF A CARBOXYLATE FOLLOWED BY CYCLIZATION WITH A BASE SUMIKA FINE CHEMICALS COMPANY, LIMITED (JP) 1998-02-10 US disclosed
EP-0735142-A2 Process for producing (R)-styrene oxides SUMIKA FINE CHEMICAL COMPANY, LTD. (JP) 1996-10-02 EP disclosed
EP-0713848-A1 Process for producing optically active carbinols SUMIKA FINE CHEMICALS Company, Limited (JP) 1996-05-29 EP disclosed