Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 3/20 | 0.47 |
| ▸ | PKM | P14618 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7454568 | 0.83 | ALOX15 (0.47) | ALOX15PKMGAAHSD17B10CDK5 | |
| SCHEMBL7458964 | 0.82 | ALOX15 (0.48) | ALOX15PKMGAAHSD17B10CDK5 | |
| SCHEMBL16502965 | 0.77 | L3MBTL1 (0.50) | PKMALDH1A1SMN1; SMN2 | |
| SCHEMBL5850777 | 0.73 | GAA (0.59) | ALOX15PKMGAAHSD17B10CDK5 | |
| SCHEMBL17319191 | 0.68 | ALOX15 (0.50) | ALOX15PKMGAAHSD17B10CDK5 | |
| SCHEMBL9176627 | 0.65 | CA1 (0.62) | PKMGAAALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL14507362 | 0.64 | CA1 (0.50) | SMN1; SMN2 | |
| SCHEMBL7998358 | 0.63 | MAPT (0.65) | ALOX15PKMGAAHSD17B10ALDH1A1 | |
| SCHEMBL4547691 | 0.62 | SMN1; SMN2 (0.44) | PKMGAAHSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL12258052 | 0.61 | ALDH1A1 (0.55) | GAAALDH1A1SMN1; SMN2TSHRTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1129108-A4 | CASPASES AND APOPTOSIS | SMITHKLINE BEECHAM CORP (US) | 2002-01-09 | — | — | EP | disclosed |
| EP-1129108-A1 | CASPASES AND APOPTOSIS | SmithKline Beecham Corporation (US) | 2001-09-05 | — | — | EP | disclosed |
| WO-2000020440-A1 | CASPASES AND APOPTOSIS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-04-13 | — | — | WO | disclosed |