Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8303679 | 0.77 | CA2 (0.49) | CA2MAPTPPARGL3MBTL1NPSR1 | |
| SCHEMBL8651760 | 0.74 | CDK2 (0.37) | CA2MAPTKMT2ANPSR1KDM4E | |
| SCHEMBL8302470 | 0.71 | CA2 (0.39) | CA2MAPTKMT2APPARGKAT6A | |
| SCHEMBL144642 | 0.70 | LMNA (0.47) | CA2AKR1B1L3MBTL1SMN1; SMN2ALDH1A1 | |
| SCHEMBL8647686 | 0.69 | AKR1B1 (0.37) | AKR1B1KMT2AKAT6AL3MBTL1NPSR1 | |
| SCHEMBL6784875 | 0.68 | F2 (0.39) | CA2MAPT | |
| SCHEMBL6754040 | 0.68 | ALDH1A1 (0.43) | CA2MAPTKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL8303252 | 0.68 | MAPT (0.41) | CA2MAPTKMT2APPARGNPSR1 | |
| SCHEMBL8647785 | 0.66 | MAPT (0.42) | CA2MAPTKMT2ANPSR1KDM4E | |
| SCHEMBL8304958 | 0.66 | GAA (0.36) | CA2MAPTKMT2AL3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0804193-A4 | THIAZOLIDINE DERIVATIVES FOR THE TREATMENT OF PSORIASIS | KURTZ THEODORE W (US) | 2002-03-27 | — | — | EP | disclosed |
| US-5824694-A | Thiazolidine derivatives for the treatment of psoriasis | BETHESDA PHARMACEUTICALS, INC. (US) | 1998-10-20 | — | — | US | disclosed |
| EP-0804193-A1 | THIAZOLIDINE DERIVATIVES FOR THE TREATMENT OF PSORIASIS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1997-11-05 | — | — | EP | disclosed |
| US-5594015-A | Thiazolidine derivatives for the treatment of psoriasis | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1997-01-14 | — | — | US | disclosed |
| WO-1995035108-A1 | THIAZOLIDINE DERIVATIVES FOR THE TREATMENT OF PSORIASIS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1995-12-28 | — | — | WO | disclosed |