Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 3/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA4 | P22748 | 1/20 | 0.43 |
| ▸ | CA6 | P23280 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | FABP4 | P15090 | 2/20 | 0.37 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.37 |
| ▸ | PRNP | P04156 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | TYMS | P04818 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2385214 | 0.88 | RXFP1 (0.46) | CA2CA1CA4CA6CDK2 | |
| SCHEMBL30987398 | 0.88 | RXFP1 (0.46) | CA2CA1CA4CA6CDK2 | |
| SCHEMBL3133065 | 0.87 | CDK2 (0.46) | CA2CA1CDK2CA9TTR | |
| SCHEMBL29904571 | 0.87 | CDK2 (0.46) | CA2CA1CDK2CA9TTR | |
| SCHEMBL15461568 | 0.79 | CA2 (0.43) | CA2CA1CA4CA6CDK2 | |
| SCHEMBL22396639 | 0.79 | TTR (0.60) | CA2CA1CA4CA6CDK2 | |
| SCHEMBL841244 | 0.78 | CA2 (0.46) | CA2CA1CA4CA6CDK2 | |
| SCHEMBL29540971 | 0.78 | CA1 (0.62) | CA2CA1CA4CA6PLCG1 | |
| SCHEMBL8071 | 0.78 | CA1 (0.62) | CA2CA1CA4CA6PLCG1 | |
| SCHEMBL9165551 | 0.77 | ALDH1A1 (0.48) | CA2CA1CDK2CA9TTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0804193-A4 | THIAZOLIDINE DERIVATIVES FOR THE TREATMENT OF PSORIASIS | KURTZ THEODORE W (US) | 2002-03-27 | — | — | EP | disclosed |
| EP-0804193-A1 | THIAZOLIDINE DERIVATIVES FOR THE TREATMENT OF PSORIASIS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1997-11-05 | — | — | EP | disclosed |
| WO-1995035108-A1 | THIAZOLIDINE DERIVATIVES FOR THE TREATMENT OF PSORIASIS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1995-12-28 | — | — | WO | disclosed |
| US-5068342-A | Hypoglycemic agents and antidiabetic agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-11-26 | — | — | US | disclosed |
| US-4997948-A | Hypoglycemic agents | AMERICAN HOME PRODUCTS (US) | 1991-03-05 | — | — | US | disclosed |
| US-4743611-A | TREATMENT OF DIABETIC COMPLICATIONS | AMERICAN HOME PRODUCTS CORP. (US) | 1988-05-10 | — | — | US | disclosed |
| EP-0251784-A2 | Naphthalenylsulfonylimidazolidinediones and their thioxo analogs | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-01-07 | — | — | EP | disclosed |
| US-4069254-A | INHIBITORS OF BLOOD PLATELET AGGREGATION | BANYU PHARMACEUTICAL CO., LTD. (JA) | 1978-01-17 | — | — | US | disclosed |