SCHEMBL74559

SCHEMBL74559

[CH2]OC(=O)C1CCOCC1

nearest known ligand 0.39

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
PIK3CD O00329 1/20 0.32
HTT P42858 1/20 0.30
KMT2A Q03164 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30
TDP1 Q9NUW8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL305397 0.82
SCHEMBL17423456 0.80 PIK3CD (0.33) PIK3CDHTTKMT2ASMN1; SMN2TDP1
SCHEMBL305004 0.77
SCHEMBL304922 0.77
SCHEMBL10318403 0.76 PIK3CD (0.32) PIK3CDHTTKMT2ASMN1; SMN2TDP1
SCHEMBL17895344 0.76 PIK3CD (0.32) PIK3CDHTTKMT2ASMN1; SMN2TDP1
SCHEMBL74560 0.76 TP53 (0.47) SMN1; SMN2
SCHEMBL1497934 0.76 ADRB2 (0.33) PIK3CD
SCHEMBL28679506 0.76 MIF (0.30)
SCHEMBL72482 0.75 CES2 (0.50) HTTKMT2ASMN1; SMN2TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 806 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3365334-B1 BENZOLACTAM COMPOUNDS AS PROTEIN KINASE INHIBITORS OTSUKA PHARMA CO LTD (JP) 2024-07-17 EP disclosed
US-20240199607-A1 BICYCLIC HETEROCYCLE COMPOUNDS AND THEIR USES IN THERAPY ASTEX THERAPEUTICS LIMITED (GB) 2024-06-20 US disclosed
US-20240197679-A1 NOVEL SHORT-ACTING PSYCHOACTIVE COMPOUNDS OF THE MDMA CLASS Altrartis Therapeutics Inc. 2024-06-20 US disclosed
US-20240199543-A1 Aza-Substituted Psilocin Analogs And Methods Of Synthesizing The Same MYDECINE INNOVATIONS GROUP INC. 2024-06-20 US disclosed
EP-4384226-A2 DIPHOSPHINE COMPOUNDS AND COMPLEXES Cancer Research Technology Limited (GB) 2024-06-19 EP disclosed
EP-4370114-A2 NOVEL SHORT-ACTING PSYCHOACTIVE COMPOUNDS OF THE MDMA CLASS Mydecine Innovations Group Inc. (US) 2024-05-22 EP disclosed
US-20240158443-A1 Compositions And Methods of Synthesizing Shape Shifting Cyclic Peptides (Sscp) And Their Use in The Identification of Novel Therapeutic Compounds UNIV COLORADO REGENTS (US) 2024-05-16 US disclosed
US-11952342-B2 Aza-substituted psilocin analogs and methods of synthesizing the same MYDECINE INNOVATIONS GROUP INC. (US) 2024-04-09 US disclosed
US-20240101513-A1 Novel Aza-Substituted Psilocin Analogs And Methods Of Synthesizing The Same MYDECINE INNOVATIONS GROUP INC. 2024-03-28 US disclosed
US-11939292-B1 Aza-substituted psilocin analogs and methods of synthesizing the same MYDECINE INNOVATIONS GROUP INC. (US) 2024-03-26 US disclosed
WO-2003082288-A1 CARBAMIC ACID COMPOUNDS COMPRISING A PIPERAZINE LINKAGE AS HDAC INHIBITORS TOPOTARGET UK LIMITED (GB) 2003-10-09 WO disclosed
EP-1330456-A2 N8,N13 -DISUBSTITUTED QUINO 4,3,2-KL]ACRIDINIUM SALTS AS THERAPEUTIC AGENTS Cancer Research Technology Limited (GB) 2003-07-30 EP disclosed
WO-2003059885-A1 THERAPEUTIC ACRIDONE AND ACRIDINE COMPOUNDS CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2003-07-24 WO disclosed
WO-2003055860-A1 3,4-DIARYLPYRAZOLES AND THEIR USE IN THE THERAPY OF CANCER VERNALIS (CAMBRIDGE) LIMITED (GB) 2003-07-10 WO disclosed
WO-2003037321-A1 ALKANE DIOL DERIVATIVES AS THERAPEUTIC AGENTS FOR THE TREATMENT OF BONE CONDITIONS THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN (GB) 2003-05-08 WO disclosed
WO-2003004479-A1 4-ARYL QUINOLS AND ANALOGS THEREOF AS THERAPEUTIC AGENTS CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2003-01-16 WO disclosed
US-20030008896-A1 Isoquinolinone derivatives KUDOS PHARMACEUTICALS LIMITED (GB) 2003-01-09 US disclosed
US-20020183325-A1 Therapy of disease of the human or animal body mediated by poly ADP-ribosyltransferase (PARP) by administering phthalazinone derivatives KUDOS PHARMACEUTICALS LIMITED (GB) 2002-12-05 US disclosed
WO-2002030932-A2 N8,N13-DISUBSTITUTED QUINO[4,3,2-KL]ACRIDINIUM SALTS AS THERAPEUTIC AGENTS CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2002-04-18 WO disclosed
WO-2002008193-A2 THERAPEUTIC ACRIDONE AND ACRIDINE COMPOUNDS CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2002-01-31 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240101513-A1 Novel Aza-Substituted Psilocin Analogs And Methods Of Synthesizing The Same TOP2A, PAICS, TOP1 PIK3CD 556/4885HTT 2725/4885KMT2A 1372/4885
US-20240197679-A1 NOVEL SHORT-ACTING PSYCHOACTIVE COMPOUNDS OF THE MDMA CLASS PNMT, HTR2C, SLC18A2 PIK3CD 3853/4885HTT 128/4885KMT2A 287/4885
US-11952342-B2 Aza-substituted psilocin analogs and methods of synthesizing the same TOP2A, PAICS, TOP1 PIK3CD 843/4885HTT 2465/4885KMT2A 1078/4885
US-20020183325-A1 Therapy of disease of the human or animal body mediated by poly ADP-ribosyltransferase (PARP) by administering phthalazinone derivatives PARP1, PARP11, PARP3 PIK3CD 4106/4885HTT 687/4885KMT2A 589/4885
US-20240158443-A1 Compositions And Methods of Synthesizing Shape Shifting Cyclic Peptides (Sscp) And Their Use in The Identification of Novel Therapeutic Compounds VIP, PTMS, QPCT PIK3CD 2622/4885HTT 1740/4885KMT2A 3377/4885
US-20030008896-A1 Isoquinolinone derivatives PARP1, PARP2, PARP3 PIK3CD 1419/4885HTT 642/4885KMT2A 1847/4885
US-20240199607-A1 BICYCLIC HETEROCYCLE COMPOUNDS AND THEIR USES IN THERAPY H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CCNB1, CCNE1 PIK3CD 4450/4885HTT 620/4885KMT2A 2579/4885
US-20240199543-A1 Aza-Substituted Psilocin Analogs And Methods Of Synthesizing The Same TOP2A, PAICS, TOP1 PIK3CD 843/4885HTT 2465/4885KMT2A 1078/4885
US-11939292-B1 Aza-substituted psilocin analogs and methods of synthesizing the same TOP2A, PAICS, TOP1 PIK3CD 843/4885HTT 2465/4885KMT2A 1078/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.