Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | PNP | P00491 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29951252 | 0.86 | KCNH2 (0.47) | TAAR1MAPT | |
| SCHEMBL26225864 | 0.84 | HRH4 (0.40) | POLBALDH1A1HRH3PNPHPGD | |
| SCHEMBL10875259 | 0.84 | L3MBTL1 (0.37) | POLBCALM1BRD4TAAR1ALDH1A1 | |
| SCHEMBL16653784 | 0.83 | HDAC1 (0.43) | HRH3MAPT | |
| SCHEMBL7349350 | 0.82 | TSHR (0.46) | HRH3ADORA2AADORA1HPGDKDM4E | |
| SCHEMBL9020936 | 0.76 | TAAR1 (0.36) | POLBBRD4TAAR1ALDH1A1HRH3 | |
| SCHEMBL1723556 | 0.76 | TAAR1 (0.48) | POLBCALM1TAAR1ALDH1A1HRH3 | |
| SCHEMBL11291277 | 0.76 | ADORA2A (0.36) | POLBBRD4TAAR1ALDH1A1HRH3 | |
| SCHEMBL6626882 | 0.74 | CALM1 (0.41) | POLBCALM1BRD4TAAR1ALDH1A1 | |
| SCHEMBL4743172 | 0.74 | CALM1 (0.41) | POLBFEN1CALM1BRD4TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118005563-A | N-benzyl imidazole derivative and preparation method and application thereof | 中国药科大学 | 2024-05-10 | — | — | CN | claimed |
| EP-0891360-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2002-05-15 | — | — | EP | disclosed |
| US-6316436-B1 | ANTICANCER AGENTS | MERCK & CO., INC. | 2001-11-13 | — | — | US | disclosed |
| WO-2000034239-A2 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2000-06-15 | — | — | WO | disclosed |
| US-6001835-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-12-14 | — | — | US | disclosed |
| EP-0891360-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-01-20 | — | — | EP | disclosed |
| WO-1997036900-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-09 | — | — | WO | disclosed |
| EP-0125783-A1 | Dopamine-beta-hydroxylase inhibitors | SMITHKLINE BECKMAN CORPORATION (US) | 1984-11-21 | — | — | EP | disclosed |