Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 12/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 12/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 10/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 10/20 | 0.41 |
| ▸ | PRSS3 | P35030 | 10/20 | 0.41 |
| ▸ | F10 | P00742 | 8/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | HRH2 | P25021 | 2/20 | 0.40 |
| ▸ | HRH1 | P35367 | 2/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | HPN | P05981 | 1/20 | 0.39 |
| ▸ | HGFAC | Q04756 | 1/20 | 0.39 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8892077 | 0.92 | ITGB3 (0.43) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| SCHEMBL7457521 | 0.86 | ITGB3 (0.51) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| SCHEMBL8894267 | 0.84 | PRSS1 (0.51) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| SCHEMBL8893028 | 0.83 | ITGB3 (0.43) | ITGB3ITGA2BTMEM97SIGMAR1HRH1 | |
| SCHEMBL7462601 | 0.82 | PRSS1 (0.41) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| SCHEMBL7461428 | 0.81 | ITGB3 (0.44) | ITGB3ITGA2BF10TMEM97SIGMAR1 | |
| SCHEMBL8894919 | 0.81 | ITGB3 (0.40) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| SCHEMBL7455413 | 0.80 | SIGMAR1 (0.42) | TMEM97SIGMAR1SLC6A2HRH2HRH1 | |
| SCHEMBL7460512 | 0.80 | ITGB3 (0.48) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| SCHEMBL8891141 | 0.80 | ITGB3 (0.40) | ITGB3ITGA2BTMEM97SIGMAR1HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0697408-B1 | 1 substituted-phenyl-oxazolidene-2-one derivatives and their use as adhesion-receptor antagonists | MERCK PATENT GMBH (DE) | 2002-01-23 | — | — | EP | disclosed |
| US-5614535-A | Adhesion receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-03-25 | — | — | US | disclosed |
| EP-0697408-A1 | 1 substituted-phenyl-oxazolidene-2-one derivatives and their use as adhesion-receptor antagonists | MERCK PATENT GmbH (DE) | 1996-02-21 | — | — | EP | disclosed |