Bromide

Bromide

SCHEMBL7457488

Br.CCCc1ccnc2ccccc12

nearest known ligand 0.58

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4

The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR1A known ✓ P08908 2/20 0.46
ADRA1D known ✓ P25100 2/20 0.46
ADRA1A known ✓ P35348 2/20 0.46
ADRA1B known ✓ P35368 2/20 0.46
LOXL2 Q9Y4K0 1/20 0.58
KDM4E B2RXH2 3/20 0.48
ALDH1A1 P00352 2/20 0.48
GAA P10253 1/20 0.48
HPGD P15428 1/20 0.48
CYP1A2 P05177 1/20 0.47
NCF1 P14598 1/20 0.47
CYP3A4 P08684 1/20 0.44
CYP2D6 P10635 1/20 0.44
HIF1A Q16665 1/20 0.44
LMNA P02545 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43
FERMT2 Q96AC1 1/20 0.41
ELANE P08246 1/20 0.40
MAPT P10636 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL528996 0.98 LOXL2 (0.60) LOXL2KDM4EALDH1A1GAAHPGD
Iodide SCHEMBL1343657 0.96 LOXL2 (0.58) LOXL2KDM4EALDH1A1GAAHPGD
SCHEMBL2237676 0.87 LOXL2 (0.56) LOXL2KDM4EALDH1A1GAAHPGD
SCHEMBL30665033 0.87 LOXL2 (0.56) LOXL2KDM4EALDH1A1GAAHPGD
SCHEMBL2364501 0.85 LOXL2 (0.55) LOXL2KDM4EALDH1A1GAAHPGD
SCHEMBL6114797 0.85 CYP19A1 (0.54) LOXL2KDM4EALDH1A1GAAHPGD
SCHEMBL6115140 0.84 LOXL2 (0.53) LOXL2KDM4EALDH1A1GAAHPGD
SCHEMBL10585446 0.84 LOXL2 (0.53) LOXL2KDM4EALDH1A1GAAHPGD
SCHEMBL6114811 0.84 LOXL2 (0.53) LOXL2KDM4EALDH1A1GAAHPGD
SCHEMBL6114551 0.84 LOXL2 (0.53) LOXL2KDM4EALDH1A1GAAHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0887182-B1 Heat-sensitive composition for making a lithographic printing form precursor KODAK POLYCHROME GRAPHICS CO (US) 2002-07-24 EP disclosed
EP-0825927-B1 LITHOGRAPHIC PRINTING FORM PRECURSOR AND ITS USE BY HEAT IMAGING KODAK POLYCHROME GRAPHICS CO (US) 1999-08-11 EP disclosed
EP-0887182-A1 Heat-sensitive composition and method of making a lithographic printing form with it HORSELL GRAPHIC INDUSTRIES LIMITED (GB) 1998-12-30 EP disclosed