Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.52 |
| ▸ | LDHA | P00338 | 2/20 | 0.42 |
| ▸ | LDHB | P07195 | 1/20 | 0.42 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.39 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.38 |
| ▸ | CTH | P32929 | 1/20 | 0.37 |
| ▸ | MME | P08473 | 2/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | SRR | Q9GZT4 | 1/20 | 0.35 |
| ▸ | ECE1 | P42892 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11300324 | 0.82 | — | — | |
| SCHEMBL9999987 | 0.82 | EGLN1 (0.62) | EGLN1LDHAPLA2G2AMAPTALDH1A1 | |
| SCHEMBL8404884 | 0.80 | EGLN1 (0.50) | EGLN1LDHALDHBPLA2G2AMAPT | |
| SCHEMBL8842594 | 0.80 | TGFBR1 (0.34) | EGLN1LDHALDHBALDH1A1LMNA | |
| SCHEMBL17075711 | 0.77 | PLA2G2A (0.47) | EGLN1LDHALDHBPLA2G2AMAPT | |
| Hydrogen Peroxide SCHEMBL8356290 | 0.77 | EGLN1 (0.44) | EGLN1LDHALDHBPLA2G2AMAPT | |
| N-Oxalylglycine SCHEMBL435820 | 0.77 | EGLN1 (0.56) | EGLN1LDHAPLA2G2AMAPTALDH1A1 | |
| SCHEMBL1765080 | 0.77 | EGLN1 (0.44) | EGLN1LDHALDHBPLA2G2AMAPT | |
| SCHEMBL289921 | 0.77 | — | — | |
| SCHEMBL13401875 | 0.76 | EGLN1 (0.50) | EGLN1LDHAPLA2G2AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103342696-B | Substituted dihydropyrazolon for treating cardiovascular and haematological diseases | BAYER SCHERING PHARMA AG | 2015-03-11 | — | — | CN | disclosed |
| CN-103342696-A | Substituted dihydropyrazolon for treating cardiovascular and haematological diseases | BAYER HEALTHCARE AG | 2013-10-09 | — | — | CN | disclosed |
| CN-101631785-B | Substituted dihydropyrazolones for the treatment of cardiovascular and hematological disorders | BAYER IP GMBH | 2013-08-21 | — | — | CN | disclosed |
| CN-101631785-A | Substituted dihydropyrazolones for the treatment of cardiovascular and hematological disorders | BAYER SCHERING PHARMA AG | 2010-01-20 | — | — | CN | disclosed |
| CN-101600710-A | Bipyridyl dihydropyrazolone that replaces and their application | BAYER HEALTHCARE AG (DE) | 2009-12-09 | — | — | CN | disclosed |
| EP-0718290-B1 | Carboxyalkyl heterocyclic derivatives | NIPPON ZOKI PHARMACEUTICAL CO (JP) | 2002-04-17 | — | — | EP | disclosed |
| US-5912261-A | ANTIDIABETIC AGENTS | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 1999-06-15 | — | — | US | disclosed |
| EP-0718290-A1 | Carboxyalkyl heterocyclic derivatives | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 1996-06-26 | — | — | EP | disclosed |