Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | PDE8B | O95263 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 4/20 | 0.33 |
| ▸ | FLT3 | P36888 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | ALPL | P05186 | 1/20 | 0.32 |
| ▸ | ALPI | P09923 | 1/20 | 0.32 |
| ▸ | ALPG | P10696 | 1/20 | 0.32 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7992626 | 0.84 | ACHE (0.41) | ACHEPDE8BL3MBTL1JAK2FLT3 | |
| SCHEMBL13181031 | 0.82 | ACHE (0.40) | ACHEPDE8BL3MBTL1MAPTKMT2A | |
| SCHEMBL1197140 | 0.81 | ACHE (0.42) | ACHEPDE8BL3MBTL1MAPTABL1 | |
| SCHEMBL13126452 | 0.79 | ACHE (0.38) | ACHEPDE8BL3MBTL1JAK2FLT3 | |
| SCHEMBL1161159 | 0.78 | ACHE (0.42) | ACHEPDE8BL3MBTL1MAPTABL1 | |
| SCHEMBL23638714 | 0.77 | TDP1 (0.39) | ACHEL3MBTL1MAPTKMT2AALDH1A1 | |
| SCHEMBL5212545 | 0.76 | ACHE (0.41) | ACHEPDE8BL3MBTL1MAPTABL1 | |
| SCHEMBL21743170 | 0.76 | GABRA1 (0.50) | ACHEPDE8BL3MBTL1MAPTABL1 | |
| SCHEMBL21303995 | 0.76 | ACHE (0.41) | ACHEPDE8BL3MBTL1MAPTABL1 | |
| SCHEMBL1106841 | 0.76 | ACHE (0.41) | ACHEPDE8BL3MBTL1MAPTABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0708102-B1 | 5-HT1F agonists for the treatment of migraine | LILLY CO ELI (US) | 2002-12-11 | — | — | EP | disclosed |
| US-5721252-A | PIPERIDINYL-1H-INDOLE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1998-02-24 | — | — | US | disclosed |
| US-5521196-A | ANALGESICS USING SEROTONIN ANTAGONIST | ELI LILLY AND COMPANY (US) | 1996-05-28 | — | — | US | disclosed |
| EP-0708102-A1 | 5-HT1F agonists for the treatment of migraine | ELI LILLY AND COMPANY (US) | 1996-04-24 | — | — | EP | disclosed |