Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6825855 | 0.89 | ALDH1A1 (0.56) | ALDH1A1CYP3A4CYP2C9CYP2C19TSHR | |
| SCHEMBL8171108 | 0.85 | ALDH1A1 (0.57) | ALDH1A1CYP3A4CYP2C9CYP2C19MAPK1 | |
| SCHEMBL7787695 | 0.84 | KMT2A (0.52) | ALDH1A1KMT2AMEN1NPC1RAB9A | |
| SCHEMBL10228581 | 0.82 | ALDH1A1 (0.53) | ALDH1A1CYP3A4CYP2C9CYP2C19TSHR | |
| SCHEMBL6825585 | 0.80 | CRBN (0.53) | ALDH1A1CYP3A4CYP2C9CYP2C19TSHR | |
| SCHEMBL27143232 | 0.79 | ALDH1A1 (0.50) | ALDH1A1CYP3A4CYP2C9CYP2C19MAPK1 | |
| SCHEMBL3387501 | 0.79 | ALDH1A1 (0.44) | ALDH1A1CYP3A4TSHRTP53KMT2A | |
| Butylcyclohexane SCHEMBL31082847 | 0.78 | CYP1A2 (0.51) | ALDH1A1CYP3A4TSHRKMT2AMEN1 | |
| SCHEMBL7321913 | 0.78 | ALDH1A1 (0.43) | ALDH1A1CYP3A4TSHRTP53KMT2A | |
| SCHEMBL7028589 | 0.78 | CYP3A4 (0.43) | ALDH1A1CYP3A4TSHRKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6448282-B1 | H3 HISTAMINE RECEPTOR ANTAGONIST ACTIVITY; ALLERGY, INFLAMMATION, CARDIOVASCULAR DISEASE, DEPRESSION, SCHIZOPHRENIA, NARCOLEPSY, SLEEP APNEA, INSOMNIA, EPILEPSY, HYPOTHALAMIC DYSFUNCTION | GLIATECH, INC. | 2002-09-10 | — | — | US | disclosed |
| EP-0841922-B1 | 1H-4(5)-SUBSTITUTED IMIDAZOLE DERIVATIVES | GLIATECH INC (US) | 2002-02-20 | — | — | EP | disclosed |
| US-6166060-A | 1H-4(5)-substituted imidazole derivatives | GLIATECH, INC. (US) | 2000-12-26 | — | — | US | disclosed |
| EP-0841922-A4 | 1H-4(5)-SUBSTITUTED IMIDAZOLE DERIVATIVES | GLIATECH INC (US) | 1999-03-10 | — | — | EP | disclosed |
| EP-0841922-A1 | 1H-4(5)-SUBSTITUTED IMIDAZOLE DERIVATIVES | GLIATECH, INC. (US) | 1998-05-20 | — | — | EP | disclosed |
| WO-1996038142-A1 | 1H-4(5)-SUBSTITUTED IMIDAZOLE DERIVATIVES | GLIATECH, INC. (US) | 1996-12-05 | — | — | WO | disclosed |