⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL160918 | 0.79 | — | — | |
| SCHEMBL2347552 | 0.79 | — | — | |
| SCHEMBL2351997 | 0.76 | HTR2A (0.32) | — | |
| SCHEMBL2345890 | 0.76 | HTR2A (0.32) | — | |
| SCHEMBL28926421 | 0.75 | RAB9A (0.34) | — | |
| SCHEMBL748238 | 0.74 | — | — | |
| SCHEMBL161217 | 0.74 | CA2 (0.36) | — | |
| SCHEMBL315488 | 0.73 | KDM4E (0.35) | — | |
| SCHEMBL20489989 | 0.72 | APP (0.31) | — | |
| SCHEMBL28410485 | 0.70 | TAAR1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101511798-A | [4, 5 '] bipyrimidinyl-6, 4' -diamine derivatives as protein kinase inhibitors | IRM LLC (VG) | 2009-08-19 | — | — | CN | claimed |
| CN-105899554-B | It is used to prepare the method for propylene terpolymers and thus obtained terpolymer | 巴塞尔聚烯烃意大利有限公司 | 2018-07-27 | — | — | CN | disclosed |
| CN-103073661-B | Magnesium dichloride-based adduct and catalytic component prepared therefrom | 巴塞尔聚烯烃意大利有限公司 | 2018-06-12 | — | — | CN | disclosed |
| CN-105143528-B | Polypropylene fibre | 巴塞尔聚烯烃意大利有限公司 | 2018-02-13 | — | — | CN | disclosed |
| CN-105408112-B | Heat-sealable polyolefins film and sheet material | 巴塞尔聚烯烃意大利有限公司 | 2018-01-19 | — | — | CN | disclosed |
| CN-107129549-A | Ingredient of solid catalyst, catalyst and application for olefinic polymerization | 中国石油化工股份有限公司 | 2017-09-05 | — | — | CN | disclosed |
| CN-107129547-A | Ingredient of solid catalyst, catalyst and application for olefinic polymerization | 中国石油化工股份有限公司 | 2017-09-05 | — | — | CN | disclosed |
| CN-107043491-A | Process for preparing impact resistant propylene polymer compositions | 巴塞尔聚烯烃意大利有限责任公司 | 2017-08-15 | — | — | CN | disclosed |
| US-9242970-B2 | Lactam derivatives useful as orexin receptor antagonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2016-01-26 | — | — | US | disclosed |
| EP-2638008-B1 | LACTAM DERIVATIVES USEFUL AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2015-07-01 | — | — | EP | disclosed |
| WO-2012063207-A1 | LACTAM DERIVATIVES USEFUL AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2012-05-18 | — | — | WO | disclosed |
| US-20120101111-A1 | NOVEL OXAZOLIDINONE DERIVIATIVES | IDORSIA PHARMACEUTICALS LTD (CH) | 2012-04-26 | — | — | US | disclosed |
| US-20120088759-A1 | THIAZOLIDIN-4-ONE AND [1,3]-THIAZINAN-4-ONE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD. (CH) | 2012-04-12 | — | — | US | disclosed |
| CN-102413828-A | Thiazolidin-4-one and [1,3] -thiazinan-4-one compounds as orexin receptor antagonists | ACTELION PHARMACEUTICALS LTD | 2012-04-11 | — | — | CN | disclosed |
| CN-102414184-A | Novel oxazolidinone derivatives and their use as orexin receptor antagonists | ACTELION PHARMACEUTICALS LTD | 2012-04-11 | — | — | CN | disclosed |
| EP-2429523-A1 | THIAZOLIDIN-4-ONE AND [1,3]-THIAZINAN-4-ONE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2012-03-21 | — | — | EP | disclosed |
| EP-2430004-A2 | NOVEL OXAZOLIDINONE DERIVATIVES AND THEIR USE AS OREXIN RECEPTOR ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2012-03-21 | — | — | EP | disclosed |
| WO-2010131191-A1 | THIAZOLIDIN-4-ONE AND [1,3]-THIAZINAN-4-ONE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2010-11-18 | — | — | WO | disclosed |
| WO-2010131192-A2 | NOVEL OXAZOLIDINONE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-11-18 | — | — | WO | disclosed |
| CN-1171394-A | New urea derivatives, their preparation and their therapeutic and prophylactic use | SANKYO CO (JP) | 1998-01-28 | — | — | CN | disclosed |