SCHEMBL315488

SCHEMBL315488

COc1[c]c(OC)c(Cl)cc1

nearest known ligand 0.35

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.35
ALDH1A1 P00352 1/20 0.35
HSD17B10 Q99714 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2350204 0.79 ALDH1A1 (0.36) KDM4EALDH1A1HSD17B10
SCHEMBL2347488 0.79 KDM4E (0.32) KDM4EALDH1A1HSD17B10
SCHEMBL2349735 0.76 KDM4E (0.34) KDM4EALDH1A1HSD17B10
SCHEMBL2351358 0.76 KDM4E (0.31) KDM4EALDH1A1HSD17B10
SCHEMBL748238 0.74
SCHEMBL161217 0.74 CA2 (0.36) KDM4EALDH1A1
SCHEMBL745940 0.73
SCHEMBL3910080 0.70 TRPV4 (0.43)
SCHEMBL5653822 0.68 ALDH1A1 (0.39) KDM4EALDH1A1
SCHEMBL7666835 0.68 MAPT (0.39) KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107629153-A Catalytic component for olefinic polymerization and preparation method thereof and the catalyst for olefinic polymerization and its application 中国石油化工股份有限公司 2018-01-26 CN claimed
CN-107629154-A Catalyst for olefinic polymerization and its preparation method and application 中国石油化工股份有限公司 2018-01-26 CN claimed
CN-107629156-A Catalytic component for olefinic polymerization and preparation method thereof and the catalyst for olefinic polymerization and its application 中国石油化工股份有限公司 2018-01-26 CN claimed
CN-107629155-A A kind of polypropylene and its preparation method and application 中国石油化工股份有限公司 2018-01-26 CN claimed
CN-104558284-B Catalytic component for olefinic polymerization and preparation method thereof and the catalyst for olefinic polymerization and application 中国石油化工股份有限公司 2017-09-29 CN claimed
CN-105899554-B It is used to prepare the method for propylene terpolymers and thus obtained terpolymer 巴塞尔聚烯烃意大利有限公司 2018-07-27 CN disclosed
CN-104448551-B Alloy composite and preparation method thereof in a kind of polypropylene 中国科学院化学研究所 2018-06-08 CN disclosed
CN-107873036-A Prepolymerized catalyst component for polymerizing olefins 巴塞尔聚烯烃意大利有限公司 2018-04-03 CN disclosed
CN-107873037-A gas phase process for polymerizing propylene 巴塞尔聚烯烃意大利有限公司 2018-04-03 CN disclosed
CN-107629154-A Catalyst for olefinic polymerization and its preparation method and application 中国石油化工股份有限公司 2018-01-26 CN disclosed
CN-107629156-A Catalytic component for olefinic polymerization and preparation method thereof and the catalyst for olefinic polymerization and its application 中国石油化工股份有限公司 2018-01-26 CN disclosed
CN-107629155-A A kind of polypropylene and its preparation method and application 中国石油化工股份有限公司 2018-01-26 CN disclosed
CN-1729176-A Tetrahydroquinoline derivatives and their use as FSH receptor modulators AKZO NOBEL NV (NL) 2006-02-01 CN disclosed
CN-1729175-A Tetrahydroquinoline derivatives AKZO NOBEL NV (NL) 2006-02-01 CN disclosed
EP-1578726-A2 TETRAHYDROQUINOLINE DERIVATIVES Akzo Nobel N.V. (NL) 2005-09-28 EP disclosed
EP-1578727-A2 TETRAHYDROQUINOLINE DERIVATIVES AND THEIR USE AS FSH RECEPTOR MODULATORS Akzo Nobel N.V. (NL) 2005-09-28 EP disclosed
US-20050154024-A1 Compounds useful in therapy PFIZER INC 2005-07-14 US disclosed
WO-2004056779-A2 TETRAHYDROQUINOLINE DERIVATIVES AND THEIR USE AS FSH RECEPTOR MODULATORS AKZO NOBEL N.V. (NL) 2004-07-08 WO disclosed
WO-2004056780-A2 TETRAHYDROQUINOLINE DERIVATIVES AKZO NOBEL N.V. (NL) 2004-07-08 WO disclosed
CN-1171394-A New urea derivatives, their preparation and their therapeutic and prophylactic use SANKYO CO (JP) 1998-01-28 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050154024-A1 Compounds useful in therapy PTGER4, PTGER3, ALOX5 KDM4E 3377/4885ALDH1A1 2650/4885HSD17B10 293/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.