Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.41 |
| ▸ | BCL2 | P10415 | 1/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | CTRC | Q99895 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9561120 | 0.85 | HTR2A (0.41) | ALOX5HTR2ACALM1BCL2BCL2L1 | |
| SCHEMBL2094181 | 0.82 | CALM1 (0.46) | ALOX5HTR2ACALM1BCL2BCL2L1 | |
| SCHEMBL8210180 | 0.77 | BCL2 (0.53) | ALOX5CALM1BCL2BCL2L1HPGD | |
| SCHEMBL7453249 | 0.77 | CALM1 (0.41) | ALOX5HTR2ACALM1BCL2BCL2L1 | |
| SCHEMBL7465412 | 0.77 | CALM1 (0.41) | ALOX5HTR2ACALM1BCL2BCL2L1 | |
| SCHEMBL27920117 | 0.77 | HTR2A (0.41) | ALOX5HTR2ACALM1BCL2BCL2L1 | |
| SCHEMBL8939761 | 0.77 | KDM4E (0.37) | ALOX5HTR2ACALM1BCL2BCL2L1 | |
| SCHEMBL28651733 | 0.76 | TAAR1 (0.43) | HTR2AKMT2APTPN1 | |
| SCHEMBL29130603 | 0.76 | CALM1 (0.39) | ALOX5HTR2ACALM1BCL2BCL2L1 | |
| SCHEMBL1584544 | 0.76 | LMNA (0.40) | HTR2AKMT2APTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105209453-A | Methylene linked quinolinyl modulators of ROR-gamma-T | JANSSEN PHARMACEUTICA NV | 2015-12-30 | — | — | CN | disclosed |
| EP-1140900-A4 | PYRAZOLE COMPOUNDS AND USES THEREOF | PPD DISCOVERY INC (US) | 2002-04-10 | — | — | EP | disclosed |
| EP-1140900-A2 | PYRAZOLE COMPOUNDS AND USES THEREOF | PPD DISCOVERY, INC. (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000039083-A2 | PYRAZOLE COMPOUNDS AND USES THEREOF | PPD DISCOVERY, INC. (US) | 2000-07-06 | — | — | WO | disclosed |