SCHEMBL7453249

SCHEMBL7453249

Cc1c[c]ccc1Cc1ccccc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CALM1 P0DP23 1/20 0.41
BCL2 P10415 1/20 0.39
BCL2L1 Q07817 1/20 0.39
CYP3A4 P08684 3/20 0.38
KDM4E B2RXH2 1/20 0.38
MAPT P10636 1/20 0.38
HTR2A P28223 1/20 0.37
CYP2D6 P10635 2/20 0.36
CYP2C19 P33261 2/20 0.36
TSHR P16473 1/20 0.36
CNR2 P34972 2/20 0.36
GPR55 Q9Y2T6 2/20 0.36
CTRC Q99895 1/20 0.36
SMN1; SMN2 Q16637 3/20 0.36
NPC1 O15118 2/20 0.36
RAB9A P51151 2/20 0.36
HPGD P15428 1/20 0.36
ALOX5 P09917 1/20 0.35
MAPK1 P28482 1/20 0.35
TDP1 Q9NUW8 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18817927 0.83 ALDH1A1 (0.34) CYP1A2
SCHEMBL2094181 0.82 CALM1 (0.46) CALM1BCL2BCL2L1CYP3A4KDM4E
SCHEMBL10492186 0.80 HTT (0.47) CYP2D6TDP1L3MBTL1CYP1A2
SCHEMBL28602103 0.78 TAAR1 (0.43) CYP3A4HTR2ACYP2D6CYP2C19TSHR
SCHEMBL8210180 0.77 BCL2 (0.53) CALM1BCL2BCL2L1CYP3A4HPGD
SCHEMBL27920117 0.77 HTR2A (0.41) CALM1BCL2BCL2L1CYP3A4HTR2A
SCHEMBL7465412 0.77 CALM1 (0.41) CALM1BCL2BCL2L1CYP3A4HTR2A
SCHEMBL7459476 0.77 ALOX5 (0.43) CALM1BCL2BCL2L1HTR2ACTRC
SCHEMBL1584610 0.77 TAAR1 (0.39) CYP3A4CYP2D6CYP2C19SMN1; SMN2HPGD
SCHEMBL275838 0.77 CALM1 (0.55) CALM1BCL2BCL2L1CYP3A4HTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106164070-A There is the macro ring picolinamide compound of Fungicidally active 美国陶氏益农公司 2016-11-23 CN disclosed
CN-105764897-A Use of macrocylic picolinamides as fungicides 美国陶氏益农公司 2016-07-13 CN disclosed
EP-1140900-A4 PYRAZOLE COMPOUNDS AND USES THEREOF PPD DISCOVERY INC (US) 2002-04-10 EP disclosed
EP-1140900-A2 PYRAZOLE COMPOUNDS AND USES THEREOF PPD DISCOVERY, INC. (US) 2001-10-10 EP disclosed
WO-2000039083-A2 PYRAZOLE COMPOUNDS AND USES THEREOF PPD DISCOVERY, INC. (US) 2000-07-06 WO disclosed
EP-0975610-A4 TRIPEPTIDE AND TETRAPEPTIDE PHARMACEUTICAL COMPOUNDS LILLY CO ELI (US) 2000-05-17 EP disclosed
EP-0975610-A1 TRIPEPTIDE AND TETRAPEPTIDE PHARMACEUTICAL COMPOUNDS ELI LILLY AND COMPANY (US) 2000-02-02 EP disclosed
WO-1998038178-A1 TRIPEPTIDE AND TETRAPEPTIDE PHARMACEUTICAL COMPOUNDS ELI LILLY AND COMPANY (US) 1998-09-03 WO disclosed