Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 3/20 | 0.53 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3864254 | 0.85 | TBXA2R (0.45) | KEAP1NFE2L2ALDH1A1KMT2AHTT | |
| SCHEMBL13589964 | 0.83 | KEAP1 (0.55) | KEAP1NFE2L2ALDH1A1SMN1; SMN2MEP1B | |
| SCHEMBL11796193 | 0.82 | KEAP1 (0.54) | KEAP1NFE2L2ALDH1A1SMN1; SMN2MEP1B | |
| SCHEMBL14502622 | 0.78 | KEAP1 (0.66) | KEAP1NFE2L2KMT2ALMNAMEN1 | |
| SCHEMBL11793398 | 0.77 | KEAP1 (0.53) | KEAP1NFE2L2KMT2ASMN1; SMN2LMNA | |
| SCHEMBL27984495 | 0.75 | MCHR1 (0.56) | ALDH1A1KMT2ASMN1; SMN2MEN1CA12 | |
| SCHEMBL6518997 | 0.75 | KEAP1 (0.65) | KEAP1NFE2L2KMT2ALMNAPOLB | |
| SCHEMBL7814402 | 0.75 | CNR2 (0.72) | KMT2APOLBMEN1HTTTAS2R14 | |
| SCHEMBL7822266 | 0.75 | KEAP1 (0.65) | KEAP1NFE2L2ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL4402780 | 0.74 | MAPT (0.57) | KEAP1NFE2L2ALDH1A1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1040098-A1 | INTEGRIN RECEPTOR ANTAGONISTS | Merck & Co., Inc. (a New Jersey corp.) (US) | 2000-10-04 | — | — | EP | disclosed |
| WO-1999031061-A1 | INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1999-06-24 | — | — | WO | disclosed |